Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
复制标题
DOI：
10.1016/j.cyto.2021.155748
复制
发表时间：
2022-01
期刊：
影响因子：
3.8
通讯作者：
McAuliffe, Fionnuala M.
中科院分区：
文献类型：
--
作者：
Kennelly, Maria A.;Killeen, Sarah Louise;Phillips, Catherine M.;Alberdi, Gouiri;Lindsay, Karen L.;Mehegan, John;Cronin, Martina;McAuliffe, Fionnuala M.
补体成分3（C3）和C反应蛋白（CRP）的循环水平升高与不良妊娠结局有关。生活方式干预可能会改善这些影响。我们调查了产前健康生活方式干预对母亲C3和CRP浓度的影响，并评估了它们与母亲和胎儿代谢标志物和结局的关系。妊娠运动与营养研究（PEARS）随机对照试验数据的次要分析。在妊娠早期（14-16周）和/或妊娠晚期（28周）测定了C3和CRP浓度并具有相应空腹血糖、胰岛素、C肽和血脂特征的女性（n = 406）纳入分析。妊娠结局包括：妊娠糖尿病（GDM）、先兆子痫（PET）或妊娠高血压（PIH）、早产（分娩< 37周）、低出生体重（<2500 g）、小于胎龄（SGA）的诊断，所述小于胎龄（SGA）使用出生体重的<第5或第10百分位数以及葡萄糖和脂质代谢的脐带血测量来定义。T检验研究了C3和CRP随时间的变化。卡方，皮尔逊相关和多元回归研究与结果的关系。PEARS干预不影响妊娠期母体C3或CRP浓度。CRP浓度与任何母亲或婴儿结局之间没有关系。发生GDM的女性在妊娠早期（p = 0.01）和妊娠晚期（p = 0.02）具有较高的C3浓度。患有PIH/PET的女性在妊娠早期（p = 0.02），但不是晚期（p = 0.10），C3浓度较低。妊娠早期母体C3浓度是妊娠早期母体胰岛素浓度的一个小但重要的预测因子。（β = 0.40，95% CI 0.27，0.53; p < 0.001）和晚期（β = 0.30，95%CI 0.17，0.43 p < 0.001）妊娠、早期总胆固醇（TC）以及早期和晚期甘油三酯、LDL和HDL胆固醇浓度（所有p < 0.001）。在妊娠早期（p < 0.001）和晚期（p = 0.01），分娩SGA婴儿（<第10百分位数）的妇女的C3浓度低于未分娩的妇女。未观察到母体C3或CRP与胎儿血糖浓度或血脂之间的关系。母体C3可能在多种不良妊娠结局中发挥作用，包括心脏代谢疾病。需要对此进行进一步研究，并制定减少妊娠人群中C3的策略。
Elevated circulating levels of complement component 3 (C3) and C-reactive protein (CRP) have been linked with adverse pregnancy outcomes. Lifestyle interventions may hold potential to ameliorate these effects. We investigated the effect of an antenatal healthy lifestyle intervention on maternal C3 and CRP concentrations and assessed their relationship with maternal and fetal metabolic markers and outcomes. Secondary analysis of data from the Pregnancy Exercise And Nutrition Research Study (PEARS) randomized controlled trial. Women (n = 406) with C3 and CRP concentrations determined in early pregnancy (14–16 weeks) and/or late pregnancy (28-weeks) with corresponding fasting glucose, insulin, c-peptide, and lipid profiles were included in the analysis. Pregnancy outcomes included: diagnoses of gestational diabetes (GDM), pre-eclampsia (PET) or pregnancy induced hypertension (PIH), pre-term birth (delivery < 37 weeks), low birth weight (<2500 g), small-for-gestational age (SGA) defined using < 5th or 10th centile for birthweight and cord blood measures of glucose and lipid metabolism. T-tests investigated changes in C3 and CRP over time. Chi-square, Pearson’s’ correlations and multiple regression investigated relationships with outcomes. The PEARS intervention did not influence maternal C3 or CRP concentrations in pregnancy. There was no relationship between CRP concentrations and any maternal or infant outcome. Women who developed GDM had higher C3 concentrations in early (p = 0.01) and late pregnancy (p = 0.02). Women who developed PIH/PET had lower C3 concentrations in early (p = 0.02), but not late (p = 0.10) pregnancy. Maternal C3 concentrations in early pregnancy were a small but significant predictor of maternal insulin concentrations in early (β = 0.40, 95% CI 0.27, 0.53; p < 0.001) and late (β = 0.30, 95% CI 0.17, 0.43p < 0.001) pregnancy, early total cholesterol (TC), and both early and late triglycerides, LDL and HDL Cholesterol concentrations (all p < 0.001). Women who delivered SGA babies (<10th centile) had lower C3 concentrations than women who did not in both early (p < 0.001) and late pregnancy (p = 0.01). No relationship between maternal C3 or CRP and fetal glucose concentrations or lipid profiles was observed. Maternal C3 may play a role in multiple adverse pregnancy outcomes including cardiometabolic ill-health. Further research on this, and strategies to reduce C3 in a pregnant population, are warranted.
登录
查看更多内容
影响因子：
3.1
作者：
Huang, Shengzhu;Tian, Jiarong;Mo, Zengnan
通讯作者：
Mo, Zengnan
影响因子：
5.8
作者：
Bo, S.;Rosato, R.;Menato, G.
通讯作者：
Menato, G.
影响因子：
2.2
作者：
Kennelly, Maria A.;Ainscough, Kate;McAuliffe, Fionnuala M.
通讯作者：
McAuliffe, Fionnuala M.
DOI：
10.1038/oby.2003.100
发表时间：
2003-06-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Gabrielsson, BG;Johansson, JM;Carlsson, LMS
通讯作者：
Carlsson, LMS
影响因子：
7.7
作者：
Engström, G;Hedblad, B;Lindgärde, F
通讯作者：
Lindgärde, F