Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
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DOI：
10.3390/metabo12100928
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发表时间：
2022-09-30
期刊：
影响因子：
4.1
通讯作者：
Perola M
中科院分区：
文献类型：
--
作者：
Sarin HV;Hulmi JJ;Qin Y;Inouye M;Ritchie SC;Cheng S;Watrous JD;Nguyen TC;Lee JH;Jin Z;Terwilliger JD;Niiranen T;Havulinna A;Salomaa V;Pietiläinen KH;Isola V;Ahtiainen JP;Häkkinen K;Jain M;Perola M
体重减轻和增加体力活动可能促进代谢组的有益调节，但关于非常低水平的体重减轻如何影响先前非肥胖活跃个体的代谢组的证据有限。经过一段减肥期（21.1 ± 3.1周），导致脂肪量减少52%（−7.9 ± 1.5 kg）和低体脂（12.7 ± 4.1%），研究了24名以前年轻，健康和体重正常的女性体格运动员的基于液相色谱-质谱的代谢特征。我们观察到体重减轻后胆汁酸、极长链游离脂肪酸（FFA）和氧脂素的均匀增加（FDR < 0.05），以及不饱和FFA的减少。这些广泛的变化，尤其是胆汁酸谱的变化，最有力地解释了（FDR < 0.05）android（内脏）脂肪量的变化。报告的变化并未持续，因为所有这些变化在随后的自愿体重恢复期（18.4 ± 2.9周）后均逆转，并且在非节食对照组（n = 16）中无变化。总的来说，我们认为，FFA，胆汁酸和oxylipin档案的变化反映了代谢适应非常低的脂肪量水平后，长时间的激烈运动和低能量的可用性。然而，上述代谢组亚类改变对代谢稳态的影响仍然存在争议，需要更多的研究来阐明复杂的生理学和潜在的相关健康影响。最后，我们的研究加强了这样一种观点，即短暂的体重减轻似乎几乎没有持久的分子和生理影响。
Weight loss and increased physical activity may promote beneficial modulation of the metabolome, but limited evidence exists about how very low-level weight loss affects the metabolome in previously non-obese active individuals. Following a weight loss period (21.1 ± 3.1 weeks) leading to substantial fat mass loss of 52% (−7.9 ± 1.5 kg) and low body fat (12.7 ± 4.1%), the liquid chromatography-mass spectrometry-based metabolic signature of 24 previously young, healthy, and normal weight female physique athletes was investigated. We observed uniform increases (FDR < 0.05) in bile acids, very-long-chain free fatty acids (FFA), and oxylipins, together with reductions in unsaturated FFAs after weight loss. These widespread changes, especially in the bile acid profile, were most strongly explained (FDR < 0.05) by changes in android (visceral) fat mass. The reported changes did not persist, as all of them were reversed after the subsequent voluntary weight regain period (18.4 ± 2.9 weeks) and were unchanged in non-dieting controls (n = 16). Overall, we suggest that the reported changes in FFA, bile acid, and oxylipin profiles reflect metabolic adaptation to very low levels of fat mass after prolonged periods of intense exercise and low-energy availability. However, the effects of the aforementioned metabolome subclass alteration on metabolic homeostasis remain controversial, and more studies are warranted to unravel the complex physiology and potentially associated health implications. In the end, our study reinforced the view that transient weight loss seems to have little to no long-lasting molecular and physiological effects.
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DOI：
10.4137/cmed.s23060
发表时间：
2015
期刊：
Clinical medicine insights. Endocrinology and diabetes
影响因子：
--
作者：
Ferraro ZM;Patterson S;Chaput JP
通讯作者：
Chaput JP
影响因子：
4.6
作者：
Chong Nguyen C;Duboc D;Rainteau D;Sokol H;Humbert L;Seksik P;Bellino A;Abdoul H;Bouazza N;Treluyer JM;Saadi M;Wahbi K;Soliman H;Coffin B;Bado A;Le Gall M;Varenne O;Duboc H
通讯作者：
Duboc H
影响因子：
16.2
作者：
Fernández-Real, JM;Broch, M;Ricart, W
通讯作者：
Ricart, W
影响因子：
5.4
作者：
Lemaitre, Rozenn N.;McKnight, Barbara;Mozaffarian, Dariush
通讯作者：
Mozaffarian, Dariush
影响因子：
4.1
作者：
Demler OV;Liu Y;Luttmann-Gibson H;Watrous JD;Lagerborg KA;Dashti H;Giulianini F;Heath M;Camargo CA Jr;Harris WS;Wohlgemuth JG;Andres AM;Tivari S;Long T;Najhawan M;Dao K;Prentice JG;Larsen JA;Okereke OI;Costenbader KH;Buring JE;Manson JE;Cheng S;Jain M;Mora S
通讯作者：
Mora S