Early-life gut microbiome composition and milk allergy resolution.
Early-life gut microbiome composition and milk allergy resolution.
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DOI：
10.1016/j.jaci.2016.03.041
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Clemente JC
中科院分区：
文献类型：
--
作者：
Bunyavanich S;Shen N;Grishin A;Wood R;Burks W;Dawson P;Jones SM;Leung DYM;Sampson H;Sicherer S;Clemente JC
肠道微生物区系可能在牛奶过敏的自然历史中发挥作用为了研究早期肠道微生物区系与牛奶过敏解决之间的关系我们研究了226名牛奶过敏儿童，他们在婴儿时期登记在食物过敏联盟(COFAR)的食物过敏观察研究中。在3-16个月大的时候收集粪便样本，并对儿童进行纵向跟踪，在登记时、6个月、12个月和此后每年进行临床评估、牛奶特异性IgE水平和牛奶皮肤点刺试验，直到8岁。肠道微生物组通过16S rRNA测序和使用QIIME(微生物生态学定量洞察)、PICRUST(通过重建未观察到的状态对群落的系统发育调查)和STAMP(元基因组图谱统计分析)进行微生物组分析。在226名儿童中，128名(56.6%)的牛奶过敏在8岁前得到缓解。3-6个月大的婴儿肠道微生物群组成与8岁前牛奶过敏消退有关(PERMANOVA P=0.047)，牛奶过敏消退的受试者的婴儿肠道微生物群中梭状芽胞杆菌和菲米米特的含量较高。元基因组功能预测支持牛奶过敏缓解受试者肠道微生物组脂肪酸代谢降低(η2=0.43，ANOVA P=0.034)。早期婴儿期是一个窗口，在此期间肠道微生物群可能会影响儿童时期的食物过敏结果。梭状芽胞杆菌和乳杆菌中的细菌分类群可以作为牛奶过敏治疗的益生菌候选进行研究。
Gut microbiota may play a role in the natural history of cow’s milk allergy To examine the association between early life gut microbiota and the resolution of cow’s milk allergy We studied 226 children with milk allergy who were enrolled at infancy in the Consortium of Food Allergy (CoFAR) observational study of food allergy. Fecal samples were collected at age 3–16 months, and the children were followed longitudinally with clinical evaluation, milk-specific IgE levels, and milk skin prick test performed at enrollment, 6 months, 12 months, and yearly thereafter up until age 8 years. Gut microbiome was profiled by 16s rRNA sequencing and microbiome analyses performed using QIIME (Quantitative Insights into Microbial Ecology), PICRUSt (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States), and STAMP (Statistical Analysis of Metagenomic Profiles). Milk allergy resolved by age 8 years in 128 (56.6%) of the 226 children. Gut microbiome composition at age 3–6 months was associated with milk allergy resolution by age 8 years (PERMANOVA P = 0.047), with enrichment of Clostridia and Firmicutes in the infant gut microbiome of subjects whose milk allergy resolved. Metagenome functional prediction supported decreased fatty acid metabolism in the gut microbiome of subjects whose milk allergy resolved (η2 = 0.43, ANOVA P = 0.034). Early infancy is a window during which gut microbiota may shape food allergy outcomes in childhood. Bacterial taxa within Clostridia and Firmicutes could be studied as probiotic candidates for milk allergy therapy.
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影响因子：
14.2
作者：
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通讯作者：
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