Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels.
Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels.
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DOI：
10.1016/j.envint.2017.11.008
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发表时间：
2018-03
影响因子：
11.8
通讯作者：
Sagiv SK
中科院分区：
文献类型：
--
作者：
Mora AM;Fleisch AF;Rifas-Shiman SL;Woo Baidal JA;Pardo L;Webster TF;Calafat AM;Ye X;Oken E;Sagiv SK
越来越多的证据表明，暴露于全氟烷基和多氟烷基物质（PFAS）可能会破坏脂质稳态和肝功能，但儿童的数据有限。我们研究了产前和儿童中期PFAS暴露与儿童血脂和丙氨酸氨基转移酶（ALT）水平的关系。我们研究了来自波士顿地区出生前队列的682对母子。我们定量了妊娠期（中位妊娠期9.7周，1999-2002年）采集的母体血浆和儿童中期（中位年龄7.7岁，2007-2010年）采集的儿童血浆中的PFAS。在儿童中期，我们还测量了空腹总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）和ALT。然后，我们使用弗里德瓦尔德公式从TC、HDL-C和TG推导出低密度脂蛋白胆固醇（LDL-C）。儿童血浆中全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和全氟癸酸（PFDeA）浓度的中位数（四分位距，IQR）分别为6.2（5.5）、4.3（3.0）和0.3（0.3）纳克/毫升。在女孩中，较高的儿童PFOS、PFOA和PFDeA浓度与血脂谱的有害变化有关，包括较高的TC和/或LDL-C [例如，全氟辛烷磺酸每IQR增量的β = TC为4.0 mg/dL（95% CI：0.3，7.8），LDL-C为2.6 mg/dL（−0.5，5.8）]。然而，在男孩和女孩中，这些儿童PFAS的较高血浆浓度也与较高的HDL-C相关，这预示着更好的心血管健康，以及略低的ALT，这可能表明更好的肝功能。产前PFAS浓度也与儿童血脂和ALT水平的改善有一定的相关性。我们的数据表明，产前和儿童中期PFAS暴露可能与儿童血脂和ALT水平的适度但有些冲突的变化有关。
Growing evidence suggests that exposure to per- and polyfluoroalkyl substances (PFASs) may disrupt lipid homeostasis and liver function, but data in children are limited. We examined the association of prenatal and mid-childhood PFAS exposure with lipids and alanine aminotransferase (ALT) levels in children. We studied 682 mother-child pairs from a Boston-area pre-birth cohort. We quantified PFASs in maternal plasma collected in pregnancy (median 9.7 weeks gestation, 1999–2002) and in child plasma collected in mid-childhood (median age 7.7 years, 2007–2010). In mid-childhood we also measured fasting total (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and ALT. We then derived low-density lipoprotein cholesterol (LDL-C) from TC, HDL-C, and TG using the Friedewald formula. Median (interquartile range, IQR) perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorodecanoate (PFDeA) concentrations in child plasma were 6.2 (5.5), 4.3 (3.0), and 0.3 (0.3) ng/mL, respectively. Among girls, higher child PFOS, PFOA, and PFDeA concentrations were associated with detrimental changes in the lipid profile, including higher TC and/or LDL-C [e.g., β per IQR increment in PFOS = 4.0 mg/dL (95% CI: 0.3, 7.8) for TC and 2.6 mg/dL (−0.5, 5.8) for LDL-C]. However, among both boys and girls, higher plasma concentrations of these child PFASs were also associated with higher HDL-C, which predicts better cardiovascular health, and slightly lower ALT, which may indicate better liver function. Prenatal PFAS concentrations were also modestly associated with improved childhood lipid and ALT levels. Our data suggest that prenatal and mid-childhood PFAS exposure may be associated with modest, but somewhat conflicting changes in the lipid profile and ALT levels in children.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
16.2
作者：
Lin CY;Chen PC;Lin YC;Lin LY
通讯作者：
Lin LY
影响因子：
8.3
作者：
Chateau-Degat, Marie-Ludivine;Pereg, Daria;Dewailly, Eric
通讯作者：
Dewailly, Eric
影响因子：
11.8
作者：
Fletcher, Tony;Galloway, Tamara S.;Harries, Lorna W.
通讯作者：
Harries, Lorna W.
影响因子：
2.6
作者：
Hundley, SG;Sarrif, AM;Kennedy, GL
通讯作者：
Kennedy, GL