Declarative memory is critical for sustained advantageous complex decision-making.
Declarative memory is critical for sustained advantageous complex decision-making.
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DOI：
10.1016/j.neuropsychologia.2009.02.007
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发表时间：
2009-06
期刊：
影响因子：
2.6
通讯作者：
Tranel D
中科院分区：
文献类型：
--
作者：
Gupta R;Duff MC;Denburg NL;Cohen NJ;Bechara A;Tranel D
关于陈述性记忆对爱荷华州赌博任务（IGT）有利决策的贡献，先前的研究报道了相互矛盾的证据。在一项研究中，在任务期间的心理生理学测量需要在卡片选择之间有10秒的延迟，该研究发现，由于海马损伤而患有健忘症的六名参与者未能发展出对有利卡片而不是不利卡片的偏好（Gutbrod等人，神经心理学，第44卷，第44页。1315-1324，2006）。然而，一个单独的案例研究（没有测量心理生理学，也没有发生卡片选择之间的延迟）表明，健忘症患者对有利的卡片产生了正常的偏好（Turnbull & Evans，Neuropsychologia，第44卷，第100页）。300-306，2006）。我们试图解决这些不一致的结果，通过检查IGT的表现，在5例患者的深度遗忘症（WMS-III一般记忆指数M =63）和缺氧（n = 4）或单纯疱疹病毒性脑炎（n = 1）引起的双侧海马损伤。在IGT的一次给药中，使用心理生理学测量，并在卡片选择之间插入6秒的延迟。在第二次给药中，未插入卡片选择之间的延迟。虽然年龄，性别和教育相匹配的健康的比较参与者表现出显着的学习与逐渐偏好的优势甲板在这两种条件下，健忘症患者，无论IGT管理条件和内侧颞叶损伤的程度，未能开发这种偏好。这些发现大大降低了卡片选择之间的延迟解释为什么健忘症参与者在IGT中无法学习的可能性，并建议内侧颞叶陈述性记忆系统在IGT所利用的复杂决策类型中发挥重要作用。
Previous studies have reported conflicting evidence concerning the contribution of declarative memory to advantageous decision-making on the Iowa Gambling Task (IGT). One study, in which the measurement of psychophysiology during the task necessitated a 10-sec delay between card selections, found that six participants with amnesia due to hippocampal damage failed to develop a preference for advantageous decks over disadvantageous decks (Gutbrod et al., Neuropsychologia, Vol. 44, pp. 1315–1324, 2006). However, a single case study (where psychophysiology was not measured and no delay between card selections occurred) showed that an amnesic patient developed normal preference for advantageous decks (Turnbull & Evans, Neuropsychologia, Vol. 44, pp. 300–306, 2006). We sought to resolve these discrepant findings by examining IGT performances in five patients with profound amnesia (WMS-III General Memory Index M =63) and bilateral hippocampal damage caused by anoxia (n = 4) or herpes simplex encephalitis (n = 1). In one administration of the IGT, psychophysiology measurements were utilized and a 6-sec delay was interposed between card selections. In a second administration, no delay between card selections was interposed. While age-, sex-, and education-matched healthy comparison participants showed significant learning with a gradual preference for advantageous decks in both conditions, amnesic patients, irrespective of IGT administration condition and extent of medial temporal lobe damage, failed to develop this preference. These findings strongly discount the possibility that the delay between card selections explains why amnesic participants fail to learn in the IGT, and suggest instead a significant role for medial temporal lobe declarative memory systems in the type of complex decision-making tapped by the IGT.
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DOI：
10.1111/j.1749-6632.2003.tb07094.x
发表时间：
2003-01-01
期刊：
AMYGDALA IN BRAIN FUNCTION: BASIC AND CLINICAL APPROACHES
影响因子：
--
作者：
Bechara, A;Damasio, H;Damasio, AR
通讯作者：
Damasio, AR
DOI：
10.1080/13803390590949287
发表时间：
2006-05-01
影响因子：
2.2
作者：
Allen, JS;Tranel, D;Damasio, H
通讯作者：
Damasio, H
影响因子：
2.6
作者：
Gutbrod, Klemens;Krouzel, Claudine;Ptak, Radek
通讯作者：
Ptak, Radek
影响因子：
1.9
作者：
MCDONALD, RJ;WHITE, NM
通讯作者：
WHITE, NM
影响因子：
56.9
作者：
Clark, RE;Squire, LR
通讯作者：
Squire, LR