Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy.
Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy.
复制标题
DOI：
10.1176/appi.ajp.2018.17070836
复制
发表时间：
2018-07-01
期刊：
影响因子：
--
通讯作者：
Hoffman MC
中科院分区：
文献类型：
--
作者：
Freedman R;Hunter SK;Hoffman MC
Genes, infection, malnutrition, and other factors affecting fetal brain development are a major component of risk for the child’s emotional development and later mental illnesses, including schizophrenia, bipolar disorder, and autism. Prenatal interventions to ameliorate that risk have yet to be established for clinical use. A systematic review of prenatal nutrients and childhood emotional development and later mental illness was performed. Randomized trials of folic acid, phosphatidylcholine, and omega-3-fatty acid supplements assess effects of doses beyond those adequate to remedy deficiencies to promote normal fetal development despite genetic and environmental risks. Folic acid to prevent neural tube defects is an example. Vitamins A and D are currently recommended at maximum levels, but women’s incomplete compliance permits observational studies of their effects. Folic acid and phosphatidylcholine supplements have shown evidence for improving childhood emotional development associated with later mental illnesses. Vitamins A and D decreased the risk for schizophrenia and autism in retrospective observations. Omega-3-fatty acid supplementation during early pregnancy increased the risk for schizophrenia and increased ADHD symptoms, but in later pregnancy decreased childhood wheezing and premature birth. Studies are complicated by the length of time between birth and the emergence of mental illnesses like schizophrenia, compared to anomalies like facial clefts identified at birth. As part of comprehensive maternal and fetal care, prenatal nutrient interventions should be further considered as uniquely effective first steps in decreasing risk for future psychiatric and other illnesses in newborn children.
登录
查看更多内容
影响因子：
4.5
作者：
Bao, YuanYuan;Ibram, Ghionul;Blaner, William S.;Quesenberry, Charles P.;Shen, Ling;McKeague, Ian W.;Schaefer, Catherine A.;Susser, Ezra S.;Brown, Alan S.
通讯作者：
Brown, Alan S.
影响因子：
1
作者：
Gossell-Williams M;Fletcher H;Zeisel SH
通讯作者：
Zeisel SH
影响因子：
17.7
作者：
Clarke, Mary C.;Tanskanen, Antti;Cannon, Mary
通讯作者：
Cannon, Mary
影响因子：
4.7
作者：
Chen, Jianzhang;Xin, Kuolin;Xiao, Huajun
通讯作者：
Xiao, Huajun
影响因子：
7.1
作者：
Cheatham, Carol L.;Goldman, Barbara Davis;Zeisel, Steven H.
通讯作者：
Zeisel, Steven H.