Imaging tumor oxyhemoglobin and deoxyhemoglobin concentrations with ultrasound-guided diffuse optical tomography.
Imaging tumor oxyhemoglobin and deoxyhemoglobin concentrations with ultrasound-guided diffuse optical tomography.
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DOI：
10.7785/tcrt.2012.500219
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发表时间：
2011-10
影响因子：
2.8
通讯作者：
Zhu Q
中科院分区：
文献类型：
--
作者：
Biswal NC;Xu Y;Zhu Q
我们提出了一种超声（US）引导下的扩散光学断层扫描映射肿瘤脱氧血红蛋白（deoxyHb）和氧合血红蛋白（oxyHb）浓度在血液幻影和体内患者。由于oxyHb和deoxyHb在不同波长下的响应不同，因此在研究中使用了波长为740 nm、780 nm、808 nm和830 nm的四个激光二极管。使用代表组织中血红蛋白氧合的不同血红蛋白氧饱和度（14%-89%）的模型进行肿瘤模型实验。不同大小和位于不同深度的目标被用来验证氧饱和度估计的准确性。在氧饱和度的测量范围内，从重建的吸收图获得的估计血红蛋白氧饱和度与使用pO 2电极获得的氧测量值之间的绝对偏差小于8%。脱氧中心核心和含氧外壳的不均匀的同心血液体模成像和deoxyHb和oxyHb地图显示相应的分布，相关性以及不均匀的脱氧和氧的分布经常出现在乳腺癌。临床实例表明，实用程序的US引导下的光学断层扫描在映射异质deoxyHb和oxyHb分布在乳腺癌。
We present an ultrasound (US)-guided diffuse optical tomography for mapping tumor deoxyhemoglobin (deoxyHb) and oxyhemoglobin (oxyHb) concentrations in blood phantoms and in in-vivo patients. Because oxyHb and deoxyHb respond differently at different wavelengths, four laser diodes of wavelengths 740 nm, 780 nm, 808 nm and 830 nm were used in the study. Tumor model experiments were performed using phantoms of different hemoglobin oxygen saturations (14%-89%) representing hemoglobin oxygenation in tissue. Targets of different sizes and located at different depths were used to validate the accuracy of oxygen saturation estimation. The absolute deviations between the estimated hemoglobin oxygen saturations obtained from reconstructed absorption maps and oxygen measurements obtained using a pO2 electrode were less than 8% over the measured range of oxygen saturation. An inhomogeneous concentric blood phantom of deoxygenated center core and oxygenated outer shell was imaged and deoxyHb and oxyHb maps revealed corresponding distributions which correlated well with inhomogeneous deoxy- and oxy-distributions frequently seen in breast cancers. Clinical examples are given to demonstrate the utility of US-guided optical tomography in mapping heterogeneous deoxyHb and oxyHb distributions in breast cancers.
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影响因子：
3.5
作者：
Cerussi, Albert;Shah, Natasha;Tromberg, Bruce J.
通讯作者：
Tromberg, Bruce J.
影响因子：
3.6
作者：
Amelink, Arjen;Christiaanse, Theo;Sterenborg, Henricus J. C. M.
通讯作者：
Sterenborg, Henricus J. C. M.
影响因子：
1.9
作者：
McBride, TO;Pogue, BW;Paulsen, KD
通讯作者：
Paulsen, KD
影响因子：
19.7
作者：
Poplack, Steven P.;Tosteson, Tor D.;Paulsen, Keith D.
通讯作者：
Paulsen, Keith D.
DOI：
10.1073/pnas.0611058104
发表时间：
2007-03-06
影响因子：
11.1
作者：
Cerussi, Albert;Hsiang, David;Tromberg, Bruce J.
通讯作者：
Tromberg, Bruce J.