Three-dimensional high-frequency backscatter and envelope quantification of cancerous human lymph nodes.
Three-dimensional high-frequency backscatter and envelope quantification of cancerous human lymph nodes.
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DOI：
10.1016/j.ultrasmedbio.2010.11.020
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发表时间：
2011-03
影响因子：
2.9
通讯作者：
Feleppa, Ernest J.
中科院分区：
文献类型：
--
作者：
Mamou, Jonathan;Coron, Alain;Oelze, Michael L.;Saegusa-Beecroft, Emi;Hata, Masaki;Lee, Paul;Machi, Junji;Yanagihara, Eugene;Laugier, Pascal;Feleppa, Ernest J.
使用高频超声（HFU）的定量成像方法提供了在微观水平上表征生物组织的手段。以前，开发了高频三维（3D）定量超声（QUS）方法来表征结直肠癌患者的46个新鲜解剖的淋巴结。使用25.6-MHz中心频率换能器采集3D超声射频数据，在组织固定之前对每个节点进行着墨，以在切片后恢复方向，用于3D组织学评价。使用3D圆柱形感兴趣区域（ROI）处理反向散射回波信号以产生与组织微结构相关联的四个QUS估计（即，有效散射体尺寸、声集中度、截距和斜率）。这些QUS估计，通过参数化的后向散射光谱，显示出巨大的潜力，癌症检测。在本研究中，这些QUS方法应用于77例结直肠癌和胃癌患者的112个淋巴结。新的QUS方法参数化的包络统计的ROI使用Nakagami和homodyned-K分布也被开发，他们产生了四个额外的QUS估计。使用ROC曲线评估这八个QUS估计对淋巴结分类和检测癌症的能力。通过结合有效散射体大小和一个基于homodyned-K分布的包络参数，获得了ROC曲线下面积为0.996，特异性和灵敏度为95%。因此，这些先进的3D QUS方法可能对检测清扫淋巴结中的小转移灶有价值。
Quantitative imaging methods using high-frequency ultrasound (HFU) offer a means of characterizing biological tissue at the microscopic level. Previously, high-frequency, three-dimensional (3D) quantitative-ultrasound (QUS) methods were developed to characterize 46 freshly-dissected lymph nodes of colorectal-cancer patients. 3D ultrasound radio-frequency data were acquired using a 25.6-MHz center-frequency transducer and each node was inked prior to tissue fixation to recover orientation after sectioning for 3D histological evaluation. Backscattered echo signals were processed using 3D cylindrical regions-of-interest (ROIs) to yield four QUS estimates associated with tissue microstructure (i.e., effective scatterer size, acoustic concentration, intercept, and slope). These QUS estimates, obtained by parameterizing the backscatter spectrum, showed great potential for cancer detection. In the present study, these QUS methods were applied to 112 lymph nodes from 77 colorectal and gastric cancer patients. Novel QUS methods parameterizing the envelope statistics of the ROIs using Nakagami and homodyned-K distributions also were developed; they yielded four additional QUS estimates. The ability of these eight QUS estimates to classify lymph nodes and detect cancer was evaluated using ROC curves. An area under the ROC curve of 0.996 with specificity and sensitivity of 95% were obtained by combining effective scatterer size and one envelope parameter based on the homodyned-K distribution. Therefore, these advanced 3D QUS methods potentially can be valuable for detecting small metastatic foci in dissected lymph nodes.
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DOI：
10.1109/tuffc.2002.1049735
发表时间：
2002-11-01
影响因子：
3.6
作者：
Hao, XH;Bruce, CJ;Greenleaf, JF
通讯作者：
Greenleaf, JF
影响因子：
2.4
作者：
Baddour, RE;Sherar, MD;Kolios, MC
通讯作者：
Kolios, MC
影响因子：
2.9
作者：
Kolios, MC;Czarnota, GJ;Sherar, MD
通讯作者：
Sherar, MD
影响因子：
2.9
作者：
Huang, Y. P.;Zheng, Y. P.;Choi, A. P. C.
通讯作者：
Choi, A. P. C.
影响因子：
2.9
作者：
Aristizábal, O;Christopher, DA;Turnbull, DH
通讯作者：
Turnbull, DH