Relationship between interictal epileptiform discharges under medetomidine sedation and clinical seizures in canine idiopathic epilepsy
Relationship between interictal epileptiform discharges under medetomidine sedation and clinical seizures in canine idiopathic epilepsy
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美托咪定镇静下发作间期癫痫样放电与犬特发性癫痫临床发作的关系
DOI：
10.1136/vr.104947
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发表时间：
2019
影响因子：
2.2
通讯作者：
Kunimi Maki
中科院分区：
文献类型：
--
作者：
Utsugi Shinichi;Saito Miyoko;Sato Toshikazu;Kunimi Maki
背景：脑电图（EEG）是诊断犬特发性癫痫所必需的，是国际兽医癫痫工作队诊断的最高置信度；然而，脑电图很少被使用，标准化的评估方法尚未见报道。方法对特发性癫痫犬和对照组在美托咪定镇静下进行脑电图分析。比较脑电图前1个月重度和轻度癫痫发作犬与对照犬的癫痫样放电（ED）频率。结果10只癫痫发作较严重的犬均发生ED， 11只癫痫发作较轻的犬中有7只发生ED。所有没有ED的癫痫犬均有良好的长期预后。癫痫发作较严重（中位数为4.5）的狗的ED频率（每五分钟ED次数）明显高于癫痫发作较轻（中位数为0.46）和对照组（中位数为0.15）的狗。ED频率大于0.8被认为是癫痫。结论美托咪定镇静作用下浅睡眠间期脑电图对ED的检出率较高，且ED频率与近期癫痫发作严重程度呈正相关。这使得间隔期脑电图记录被用作一种简化和客观的测试，可能有助于诊断癫痫和评估狗的疾病最近的严重程度。
BackgroundElectroencephalography (EEG) is required for the diagnosis of canine idiopathic epilepsy as a highest confidence level of diagnosis by the International Veterinary Epilepsy Task Force; however, EEG is seldom used and a standardised assessment method has not been reported.MethodsInterictal EEG was performed under medetomidine sedation in dogs with idiopathic epilepsy and in control dogs. Epileptiform discharge (ED) frequency was compared between dogs with more severe and less severe seizures during one month before EEG and control dogs.ResultsAll 10 dogs with more severe seizures had ED, as had 7 of 11 with less severe seizures. All epileptic dogs without ED had good long‐term outcomes. ED frequency (number of ED per five minutes) was significantly higher in dogs with more severe (median, 4.5) than with less severe seizure (median, 0.46) and in the control dogs (median, 0.15). An ED frequency greater than 0.8 was considered to indicate epilepsy.ConclusionInterictal EEG in a light sleep state under medetomidine sedation had a high detection rate of ED, and ED frequency had a positive correlation with the recent severity of epileptic seizures. This allows interictal EEG recordings to be used as a simplified and objective test that may help to diagnose epilepsy and to assess the recent severity of the disease in dogs.
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DOI：
--
发表时间：
2018
期刊：
影响因子：
--
作者：
G. Togawa;M. Saito;Itsuki Uebayashi;Y. Ohnishi;Hinako Yamazoe
通讯作者：
Hinako Yamazoe
影响因子：
9.9
作者：
WHITE, JC;LANGSTON, JW;PEDLEY, TA
通讯作者：
PEDLEY, TA
DOI：
10.1016/s1096-2867(98)80034-0
发表时间：
1998-08-01
期刊：
CLINICAL TECHNIQUES IN SMALL ANIMAL PRACTICE
影响因子：
--
作者：
Holliday, TA;Williams, DC
通讯作者：
Williams, DC
影响因子：
0.9
作者：
Pakozdy, Akos;Thalhammer, Johann G.;Halasz, Peter
通讯作者：
Halasz, Peter
DOI：
10.1177/155005947500600305
发表时间：
1975
期刊：
影响因子：
--
作者：
Y. Koshino;E. Niedermeyer
通讯作者：
E. Niedermeyer