Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter.
Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter.
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在健康的老年女性中，端粒损耗的决定因素：压力和健康行为很重要。
DOI：
10.1038/mp.2014.70
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发表时间：
2015-04
影响因子：
11
通讯作者：
Epel, E. S.
中科院分区：
文献类型：
--
作者：
Puterman, E.;Lin, J.;Krauss, J.;Blackburn, E. H.;Epel, E. S.
端粒长度是疾病发病机制的可靠预测因子，可受到遗传、慢性压力和健康行为的影响。从横截面上看，高度压力的绝经后妇女的端粒较短，但只有在她们不活动的情况下。然而，没有研究前瞻性地研究端粒长度在短时间内的变化，以及磨损率是否受到自然因素的影响，如压力和健康行为的参与。在这里，我们对健康女性进行了一年多的跟踪调查，以测试一年中发生的主要压力源是否可以预测端粒缩短，以及在此期间从事健康行为是否可以减轻这种影响。在239名绝经后、不吸烟、无疾病的女性中，一年内主要生活压力源的积累预测了同一时期的端粒损耗-对于一年内发生的每一个主要生活压力源，端粒长度在一年内的下降幅度都要大得多，为35个碱基对（p <0.05）。然而，这些影响受到健康行为的调节（交互作用B = 0.19，p = 0.04）。保持相对较高水平的健康行为（高于平均值一个标准差）的女性在暴露于压力时似乎受到保护。这一发现对于理解端粒长度的延展性以及对可能的干预效果的预期具有意义。这是第一个确定端粒长度在一年内变化的预测因素的研究。
Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress, and health behaviors. Cross-sectionally, highly stressed post-menopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors. Here we followed healthy women over one year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect. In 239 post-menopausal, non-smoking, disease-free women, accumulation of major life stressors across a one-year period predicted telomere attrition over the same period - for every major life stressor that occurred during the year, there was a significantly greater decline in telomere length over the year of 35 base pairs (p < .05). Yet, these effects were moderated by health behaviors (interaction B = 0.19, p = .04). Women who maintained relatively higher levels of health behaviors (one standard deviation above the mean) appeared to be protected when exposed to stress. This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects. This is the first study to identify predictors of telomere length change over the short period of a year.
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影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
影响因子：
4.8
作者：
Andreazza, Ana C.;Andersen, Monica L.;Tufik, Sergio
通讯作者：
Tufik, Sergio
DOI：
10.1038/nrg3246
发表时间：
2012-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.