Sleeve gastrectomy prevents hypertension associated with unique shifts in the gut microbiome.
Sleeve gastrectomy prevents hypertension associated with unique shifts in the gut microbiome.
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DOI：
10.1007/s00464-020-08036-y
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Kindel T
中科院分区：
文献类型：
--
作者：
Barron M;Atkinson SN;Kirby J;Kindel T
减肥手术导致超过50%的患者的高血压消退。虽然体重减轻是减肥手术后高血压消退的关键组成部分，但也可能存在与体重减轻无关的机制。我们假设袖状胃切除术（SG）会引发肠道微生物组的变化，从而降低术后血压。雄性肥胖Zucker大鼠接受SG、成对喂食假手术或自由喂食假手术。术前1周、术后2周和术后6周进行血压测量。术后6周通过16S rDNA基因测定粪便微生物组组成。进行回归随机森林建模以确定微生物组成与血压的关联。在整个手术后期间，SG和配对喂食大鼠的体重显著低于自由喂食假手术大鼠。在手术后6周，SG大鼠的收缩压（149.2 ± 1.99 mmHg）显著低于配对喂养（164.7 ± 7.87，p<0.001）或随意喂养的假手术大鼠（167.1 ± 2.41 mmHg，p<0.001）。SG大鼠与配对喂养和随意喂养的假手术大鼠之间的β多样性的多个测量值存在显著差异。回归随机森林模型解释了样本间血压变异性差异的45.11%。大鼠模型中的SG可独立于体重减轻阻止高血压进展，并改变与血压结果相关的β多样性和肠道细菌组成。这些发现进一步支持了SG在治疗高血糖症、心功能不全和高血压方面的代谢疗效，与肥胖类别无关。
Bariatric surgery results in resolution of hypertension in over 50% of patients. While weight loss is a critical component to hypertension resolution after bariatric surgery, there may also be weight loss independent mechanisms. We hypothesized that sleeve gastrectomy (SG) initiates changes in the gut microbiome which reduce post-operative blood pressure. Male, obese Zucker rats underwent SG, pair-fed sham, or ad-lib fed sham surgery. Blood pressure measurements were performed one week pre-operatively, and at 2 and 6 weeks post-operatively. The stool microbiome composition was determined by 16S rDNA gene at 6 weeks post-operatively. Regression Random Forest modeling was performed to determine an association of the microbial composition with blood pressure. SG and pair-fed rats weighed significantly less than ad-lib fed sham rats through-out the post-surgical period. At 6 weeks after surgery, SG rats had a significantly lower systolic blood pressure (149.2 ± 1.99 mmHg) than pair-fed (164.7 ± 7.87, p<0.001) or ad-lib fed sham rats (167.1 ± 2.41 mmHg, p<0.001). There was a significant difference in multiple measures of beta diversity between SG rats and pair-fed and ad-lib fed sham rats. 45.11% of the difference in blood pressure variability between samples was explained with the regression Random Forest model. SG in a rat model prevented hypertension progression independent of weight loss with changes in beta diversity and gut bacterial composition associated with the blood pressure outcome. These findings further support the metabolic efficacy of SG in treating hyperglycemia, cardiac dysfunction, and now hypertension, independent of obesity class.
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影响因子：
48
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