Multishot PROPELLER for high-field preclinical MRI.

Multishot PROPELLER for high-field preclinical MRI.
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用于高场强临床前磁共振成像的多光点 PROPELLER。

DOI:
10.1002/mrm.22376
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发表时间:
2010-07
影响因子:
3.3
通讯作者:
Johnson, G. Allan
Johnson, G. Allan
中科院分区:
医学3区
文献类型:
--
作者:
Pandit, Prachi;Qi, Yi;Story, Jennifer;King, Kevin F.;Johnson, G. Allan

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随着许多小鼠癌症模型的发展,非常需要适当的成像技术来研究疾病的演变。使用PROPELLER MRI的高场T2加权成像满足了这一需求。本文介绍的2次PROPELLER技术提供了(a)高空间分辨率,(B)高对比度分辨率,以及(c)快速和非侵入性成像,这使得能够在自由呼吸小鼠中进行高通量纵向研究。独特的数据收集和重建使得该方法对运动伪影具有鲁棒性。这里介绍的双激发修改,保留了更多的高频信息,并提供比传统的单激发PROPELLER更高的SNR,使该序列在信号损失迅速的高场是可行的。结果显示在肝转移模型中,以证明该技术在小鼠的一个更具挑战性的区域(腹部)中的实用性。
With the development of numerous mouse models of cancer, there is a tremendous need for an appropriate imaging technique to study the disease evolution. High-field T2-weighted imaging using PROPELLER MRI meets this need. The 2-shot PROPELLER technique presented here, provides (a) high spatial resolution, (b) high contrast resolution, and (c) rapid and non-invasive imaging, which enables high-throughput, longitudinal studies in free-breathing mice. Unique data collection and reconstruction makes this method robust against motion artifacts. The 2-shot modification introduced here, retains more high-frequency information and provides higher SNR than conventional single-shot PROPELLER, making this sequence feasible at high-fields, where signal loss is rapid. Results are shown in a liver metastases model to demonstrate the utility of this technique in one of the more challenging regions of the mouse, which is the abdomen.
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