Effect of exercise on dopamine neuron survival in prenatally stressed rats.
Effect of exercise on dopamine neuron survival in prenatally stressed rats.
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DOI：
10.1007/s11011-009-9161-6
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发表时间：
2009-12
影响因子：
3.6
通讯作者：
Russell, Vivienne A.
中科院分区：
文献类型：
--
作者：
Mabandla, Musa V.;Kellaway, Lauriston A.;Daniels, William M. U.;Russell, Vivienne A.
产前压力与精神障碍的易感性增加有关，包括精神分裂症、抑郁症、注意力缺陷多动障碍和自闭症。母体循环应激激素升高会改变胎儿大脑神经回路的发育，并导致行为的长期变化。本研究的目的是调查轻度产前应激是否会增加成年后多巴胺神经元的脆弱性。将低剂量的6-羟基多巴胺（6-OHDA，5 μg/4 μl生理盐水）单侧注入大鼠大脑的内侧前脑神经纤维束，以造成多巴胺神经元的部分损伤，这足以引起与帕金森病早期发作相关的轻微行为缺陷，而不完全破坏多巴胺神经元。自愿运动似乎具有神经保护作用，导致运动控制的改善和使用左右前肢探索新环境时的不对称性降低，以及黑质黑质腹侧部酪氨酸羟化酶阳性细胞的不对称性降低和6-OHDA损伤大鼠多巴胺细胞丢失减少。产前应激可能通过降低对运动的代偿性适应来增强6-OHDA的毒性作用。
Prenatal stress has been associated with increased vulnerability to psychiatric disturbances including schizophrenia, depression, attention-deficit hyperactivity disorder and autism. Elevated maternal circulating stress hormones alter development of neural circuits in the fetal brain and cause long-term changes in behaviour. The aim of the present study was to investigate whether mild prenatal stress increases the vulnerability of dopamine neurons in adulthood. A low dose of 6-hydroxydopamine (6-OHDA, 5 μg/4 μl saline) was unilaterally infused into the medial forebrain bundle of nerve fibres in the rat brain in order to create a partial lesion of dopamine neurons which was sufficient to cause subtle behavioural deficits associated with early onset of Parkinson’s disease without complete destruction of dopamine neurons. Voluntary exercise appeared to have a neuroprotective effect resulting in an improvement in motor control and decreased asymmetry in the use of left and right forelimbs to explore a novel environment as well as decreased asymmetry of tyrosine hydroxylase-positive cells in the substantia nigra pars compacta and decreased dopamine cell loss in 6-OHDA-lesioned rats. Prenatal stress appeared to enhance the toxic effect of 6-OHDA possibly by reducing the compensatory adaptations to exercise.
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影响因子：
2.7
作者：
Darnaudéry, M;Dutriez, I;Maccari, S
通讯作者：
Maccari, S
影响因子：
3.6
作者：
Mabandla, M;Kellaway, L;Russell, VA
通讯作者：
Russell, VA
影响因子：
4.1
作者：
SWANSON, LW;SAWCHENKO, PE
通讯作者：
SAWCHENKO, PE
影响因子：
3.2
作者：
Lesage, J;Dufourny, L;Dupouy, JP
通讯作者：
Dupouy, JP
影响因子：
--
作者：
MARCONDES, F. K.;BIANCHI, F. J.;TANNO, A. P.
通讯作者：
TANNO, A. P.