The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A.
The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A.
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DOI：
10.1007/s12032-007-9020-4
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kitamura S
中科院分区：
文献类型：
--
作者：
Ishibashi J;Yamashita K;Ishikawa T;Hosokawa H;Sumida K;Nagayama M;Kitamura S
我们开发了一种组织培养箱，可以用波长在 4 至 20 μm 之间、峰值为 7-12 μm 的远红外辐射 (FIR) 持续照射细胞，发现 FIR 对 A431（外阴）、HSC3（舌）、Sa3（牙龈）、A549（肺）和 MCF7（乳腺癌）五种人类癌细胞系产生不同的抑制作用。然后，为了明确FIR作用的控制系统，对与FIR抑制作用相关的基因表达进行了分析。因此，A431 和 MCF7 细胞中 HSP70A mRNA 的基础表达水平高于 FIR 敏感的 HSC3、Sa3 和 A549 细胞。此外，HSP70 的过度表达抑制了 FIR 诱导的 HSC3 细胞生长停滞，并且 HSP70 siRNA 通过 FIR 照射抑制了 A431 细胞的增殖。这些结果表明，FIR抑制某些癌细胞增殖的体温范围的效果是受热休克蛋白(HSP)70A的基础表达水平控制的。这一发现表明，FIR 对于某些 HSP70 水平较低的癌细胞来说应该是非常有效的治疗方法。更重要的是，如果测量患者的任何癌症中的HSP70水平，则可以预见FIR对该癌症的治疗效果。
We developed a tissue culture incubator that can continuously irradiate cells with far-infrared radiation (FIR) of wavelengths between 4 and 20 μm with a peak of 7–12 μm, and found that FIR caused different inhibiting effects to five human cancer cell lines, namely A431 (vulva), HSC3 (tongue), Sa3 (gingiva), A549 (lung), and MCF7 (breast). Then, in order to make clear the control system for the effect of FIR, the gene expression concerned to the inhibition effect by FIR were analyzed. In consequence, basal expression level of HSP70A mRNA was higher in A431 and MCF7 cells than in the FIR-sensitive HSC3, Sa3, and A549 cells. Also, the over expression of HSP70 inhibited FIR-induced growth arrest in HSC3 cells, and an HSP70 siRNA inhibited the proliferation of A431 cells by irradiation with FIR. These results indicate that the effect of a body temperature range of FIR suppressing the proliferation of some cancer cells is controlled by the basal expression level of heat shock protein (HSP) 70A. This finding suggested that FIR should be very effective medical treatment for some cancer cells which have a low level of HSP70. Still more, if the level of HSP70 in any cancer of a patient was measured, the effect of medical treatment by FIR can be foreseen for the cancer.
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影响因子：
6.6
作者：
KAVER, I;WARE, JL;KOONTZ, WW
通讯作者：
KOONTZ, WW
影响因子：
2.5
作者：
Teraoka, F;Hamada, Y;Takahashi, J
通讯作者：
Takahashi, J
DOI：
10.1016/0360-3016(91)90068-f
发表时间：
1991-03-01
影响因子：
7
作者：
KAPLAN, I;KAPP, DS;BAGSHAW, MA
通讯作者：
BAGSHAW, MA
影响因子：
3.5
作者：
Bellmann, K;Jaattela, M;Kolb, H
通讯作者：
Kolb, H
影响因子：
3.2
作者：
HONDA, K;INOUE, S
通讯作者：
INOUE, S