High Pulse Wave Velocity Is Associated With Decreased Macular Vessel Density in Normal-Tension Glaucoma.
High Pulse Wave Velocity Is Associated With Decreased Macular Vessel Density in Normal-Tension Glaucoma.
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DOI：
10.1167/iovs.62.10.12
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发表时间：
2021-08-02
影响因子：
4.4
通讯作者：
Lee SY
中科院分区：
文献类型：
--
作者：
Lee T;Bae HW;Seong GJ;Kim CY;Lee SY
探讨正常眼压性青光眼（NTG）患者脉搏波传导速度（PWV）与光学相干断层扫描血管造影（OCTA）测量的视网膜血管密度（VD）的关系。这项回顾性研究包括103名NTG患者和109名健康对照者，他们接受了青光眼检查和PWV测量。根据臂踝PWV 1400 cm/s分为两个亚组。当在存在青光眼性视盘（神经视网膜边缘变薄和凹陷）、视乳头周围视网膜神经纤维层缺损和青光眼性视野缺损的情况下，在不同时间获得的三次重复测量的最大未经治疗的眼内压< 21 mmHg时，诊断为NTG。健康对照组无青光眼性视盘或视野缺损，视网膜神经纤维层厚度正常。青光眼检查和PWV测量之间的间隔不超过6个月。进行单因素和多因素logistic回归分析，以确定与高PWV相关的因素。NTG组PWV高于对照组，而视盘周围血管密度（MVD）和黄斑区血管密度（MVD）低于对照组（P均< 0.05）。逐步Logistic回归分析显示，高PWV与NTG组的年龄、平均动脉压（MAP）和MVD显著相关。同时，在健康对照组中，高PWV与年龄、MAP和低密度脂蛋白胆固醇水平显著相关。高PWV与NTG患者的MVD降低相关，提示全身动脉僵硬度可能参与NTG的发病机制。
To investigate the relationship between pulse wave velocity (PWV) and retinal vessel density (VD) measured by optical coherence tomography angiography (OCTA) in patients with normal-tension glaucoma (NTG). This retrospective study included 103 patients with NTG and 109 healthy controls who underwent glaucoma examination and PWV measurements. Each group was classified into two subgroups according to a brachial-ankle PWV of 1400 cm/s. NTG was diagnosed when the maximum untreated intraocular pressure was < 21 mmHg on three repeated measurements obtained at different times in the presence of glaucomatous optic discs (neuroretinal rim thinning and excavation), peripapillary retinal nerve fiber layer defects, and glaucomatous visual field defects. Healthy controls did not have glaucomatous optic discs or visual field defects and exhibited normal retinal nerve fiber layer thickness. The interval between glaucoma examination and PWV measurements did not exceed six months. Univariate and multivariate logistic regression analyses were performed to identify factors associated with high PWV. PWV was higher in the NTG group than in the control group, while peripapillary VD and macular VD (mVD) were lower (all P < 0.05). Stepwise logistic regression analysis revealed that high PWV was significantly associated with age, mean arterial pressure (MAP), and mVD in the NTG group. Meanwhile, high PWV was significantly associated with age, MAP, and low-density lipoprotein cholesterol levels in healthy controls. High PWV is associated with decreased mVD in NTG patients, suggesting that systemic arterial stiffness might be involved in the pathogenesis of NTG.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.7
作者：
Bojikian KD;Chen CL;Wen JC;Zhang Q;Xin C;Gupta D;Mudumbai RC;Johnstone MA;Wang RK;Chen PP
通讯作者：
Chen PP
DOI：
10.1007/s00417-009-1271-7
发表时间：
2010-03-01
影响因子：
2.7
作者：
Kaderli, Aysel Aydin;Kaderli, Berkant;Avci, Remzi
通讯作者：
Avci, Remzi
影响因子：
2.8
作者：
Chung, Tae-Ha;Shim, Jae-Yong;Lee, Yong-Jae
通讯作者：
Lee, Yong-Jae
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R