Ocular biometry and open-angle glaucoma: the Los Angeles Latino Eye Study.

Ocular biometry and open-angle glaucoma: the Los Angeles Latino Eye Study.
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DOI:
10.1016/j.ophtha.2010.01.035
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发表时间:
2010-09
期刊:
影响因子:
13.7
通讯作者:
Los Angeles Latino Eye Study Group
Los Angeles Latino Eye Study Group
中科院分区:
医学1区
文献类型:
--
作者:
Kuzin AA;Varma R;Reddy HS;Torres M;Azen SP;Los Angeles Latino Eye Study Group

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在拉丁美洲成年人群中,研究近视屈光不正(MRE)、角膜屈光力(CP)、眼轴长度(AL)与开角型青光眼(OAG)患病率之间的关系。基于人群的横断面流行病学研究。洛杉矶拉丁裔眼科研究(LALES)中的5927名40岁及以上的拉丁裔。MRE定义为≤-1屈光度(D)的非睫状肌麻痹球柱屈光不正。用A型超声测量AL。使用Humphrey自动验光仪测量CP。OAG的诊断是视神经和视野的变化相结合。从分析中排除了人工晶状体眼和无晶状体眼。采用logistic回归模型计算MRE、AL、CP和OAG患病率之间的相关性,校正年龄、性别、眼内压、中央角膜厚度、糖尿病、青光眼家族史和透镜核混浊(NO)。OAG患病率的比值比(OR)。调整协变量后,MRE较大的人(OR 1.82,1.20-2.77; P=0.005),AL较长(OR:1.25,1.03-1.50; P=0.02)和角膜平坦(OR 1.21,1.08-1.35; P=0.0007)与OAG的患病率较高,分别与正视眼屈光不正、眼轴长度较短和角膜较陡的患者相比。有近视屈光不正、角膜较平和眼轴较长的人应被认为有较高的开角型青光眼风险。
To examine the associations between myopic refractive error (MRE), corneal power (CP), axial length (AL), and the prevalence of open angle glaucoma (OAG) in an adult Latino population. Population-based cross-sectional epidemiologic study. 5927 Latinos aged 40 years and older in the Los Angeles Latino Eye Study (LALES). MRE was defined as a non-cycloplegic sphero-cylindrical refractive error of ≤ −1 diopter (D). AL was measured by A-scan ultrasound. CP was measured using a Humphrey auto-refractor. OAG was diagnosed by a combination of optic nerve and visual field changes. Pseudophakic and aphakic eyes were excluded from the analysis. The associations between MRE, AL, CP, and the prevalence of OAG were calculated using a logistic regression model, adjusting for age, gender, intraocular pressure, central corneal thickness, diabetes mellitus, family history of glaucoma, and lens nuclear opacification (NO). Odds ratios (OR) for the prevalence of OAG. After adjusting for covariates persons with greater MRE (OR 1.82, 1.20–2.77; P=0.005), longer AL (OR: 1.25, 1.03–1.50; P=0.02) and flatter corneas (OR 1.21, 1.08–1.35; P=0.0007) were associated with a higher prevalence of OAG when compared to those with emmetropic refractive error, shorter axial length and steeper corneas respectively. Persons with a myopic refractive error, flatter corneas, and longer axial lengths should be considered to be at higher risk of having open-angle glaucoma.
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