Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients.
Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients.
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皮层下血管轻度认知障碍和遗忘轻度认知障碍患者海马亚区全脑结构协方差的改变
DOI：
10.3389/fneur.2018.00342
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发表时间：
2018
影响因子：
3.4
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Wang X;Yu Y;Zhao W;Li Q;Li X;Li S;Yin C;Han Y
海马体在记忆加工中起着重要作用。然而，海马体并不是一个均匀的结构，它由几个子区组成。许多神经退行性疾病，特别是轻度认知障碍（MCI）对海马亚区有不同的影响。遗忘性轻度认知障碍（aMCI）和皮层下血管性轻度认知障碍（svMCI）是轻度认知障碍的两种亚型。aMCI的特征是情景性记忆丧失，而svMCI的特征是磁共振成像上广泛的白质高信号和多发腔隙性梗死。svMCI的主要认知障碍是执行功能、注意力和语义记忆。在aMCI和svMCI患者中观察到特定大尺度脑网络中的一些变异或断开。本研究的目的是探讨aMCI和svMCI患者海马亚区与整个大脑皮层之间的结构协方差网络（scn）的异常情况，以及这些异常在两组之间是否存在差异。使用FreeSurfer 5.3对海马亚区进行自动分割，我们选择了5个海马亚区作为SCN分析的种子：CA1、CA2/3、CA4/齿状回（DG）、枕下和枕前。基于这些海马亚区种子构建各组的scn。各组海马亚区、梭状回（FFG）和内嗅皮质（ERC）灰质体积均存在显著相关性。我们还比较了任意两组间结构协方差强度的差异。在aMCI组，与正常对照（NC）组相比，我们观察到左侧CA1/CA4/DG/下骨与左侧颞极之间的相关性增加。此外，与NC组相比，svMCI组海马亚区（双侧CA1，左侧CA2/3）与眶额皮质显著共变。在aMCI组中，与svMCI组相比，我们观察到海马亚区与右侧FFG之间的关联减少，同时我们还观察到双侧枕下/枕前与双侧ERC之间的关联增加。这些发现提供了svMCI和aMCI患者海马亚区全脑结构协方差改变的新证据，并为不同MCI亚型的病理机制提供了新的见解。
The hippocampus plays important roles in memory processing. However, the hippocampus is not a homogeneous structure, which consists of several subfields. The hippocampal subfields are differently affected by many neurodegenerative diseases, especially mild cognitive impairment (MCI). Amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) are the two subtypes of MCI. aMCI is characterized by episodic memory loss, and svMCI is characterized by extensive white matter hyperintensities and multiple lacunar infarctions on magnetic resonance imaging. The primary cognitive impairment in svMCI is executive function, attention, and semantic memory. Some variations or disconnections within specific large-scale brain networks have been observed in aMCI and svMCI patients. The aim of this study was to investigate abnormalities in structural covariance networks (SCNs) between hippocampal subfields and the whole cerebral cortex in aMCI and svMCI patients, and whether these abnormalities are different between the two groups. Automated segmentation of hippocampal subfields was performed with FreeSurfer 5.3, and we selected five hippocampal subfields as the seeds of SCN analysis: CA1, CA2/3, CA4/dentate gyrus (DG), subiculum, and presubiculum. SCNs were constructed based on these hippocampal subfield seeds for each group. Significant correlations between hippocampal subfields, fusiform gyrus (FFG), and entorhinal cortex (ERC) in gray matter volume were found in each group. We also compared the differences in the strength of structural covariance between any two groups. In the aMCI group, compared to the normal controls (NC) group, we observed an increased association between the left CA1/CA4/DG/subiculum and the left temporal pole. Additionally, the hippocampal subfields (bilateral CA1, left CA2/3) significantly covaried with the orbitofrontal cortex in the svMCI group compared to the NC group. In the aMCI group compared to the svMCI group, we observed decreased association between hippocampal subfields and the right FFG, while we also observed an increased association between the bilateral subiculum/presubiculum and bilateral ERC. These findings provide new evidence that there is altered whole-brain structural covariance of the hippocampal subfields in svMCI and aMCI patients and provide insights to the pathological mechanisms of different MCI subtypes.
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影响因子：
3.7
作者：
Bai F;Xie C;Watson DR;Shi Y;Yuan Y;Wang Y;Yue C;Teng Y;Wu D;Zhang Z
通讯作者：
Zhang Z
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
2.6
作者：
Kim, Sook Hui;Kang, Hyun Seok;Han, Seol-Heui
通讯作者：
Han, Seol-Heui
影响因子：
5.7
作者：
Koch, Kathrin;Reess, Tim Jonas;Zimmer, Claus
通讯作者：
Zimmer, Claus