The odor of Osmanthus fragrans attenuates food intake.
The odor of Osmanthus fragrans attenuates food intake.
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DOI：
10.1038/srep01518
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发表时间：
2013
影响因子：
4.6
通讯作者：
Tsuji, Tadataka
中科院分区：
文献类型：
--
作者：
Yamamoto, Takashi;Inui, Tadashi;Tsuji, Tadataka
气味已被证明对各种生理和行为活动产生影响。然而，人们对气味刺激是否直接影响进食相关神经肽的水平知之甚少。在这里，我们发现桂花（OSM）的神经传递降低了大鼠中促食欲神经肽的mRNA表达，例如刺鼠相关蛋白、神经肽Y、黑色素浓缩激素和前食欲素原，同时增加了促食欲神经肽的mRNA表达，例如可卡因和安非他明调节的转录物和阿片黑皮素原。下丘脑中食欲素免疫反应性神经元数量的减少与 OSM 诱导的前食欲素原 mRNA 表达的减少非常吻合。这项研究表明，已知具有轻微镇静作用的 OSM 气味会降低进食动机、食物摄入量和体重，并伴有咀嚼运动迟缓。数据表明，这些作用是由于下丘脑中促食欲神经肽的抑制和促食欲神经肽的激活所致。
Odors have been shown to exert an influence on various physiological and behavioral activities. However, little is known whether or not odor stimulation directly affects the levels of feeding-related neuropeptides. Here we show that the neural transmission by Osmanthus fragrans (OSM) decreased the mRNA expression of orexigenic neuropeptides, such as agouti-related protein, neuropeptide Y, melanin-concentrating hormone and prepro-orexin, while increased anorexigenic neuropeptides, such as cocaine- and amphetamine-regulated transcript and proopiomelanocortin in rats. The decreased number of orexin-immunoreactive neurons in the hypothalamus coincided well with the OSM-induced decreases in the expression of prepro-orexin mRNA. This study demonstrates that the OSM odor, which is known to have a mild sedative effect, decreases the motivation to eat, food intake and body weight, accompanied by sluggish masticatory movements. The data suggest that these effects are due to suppression of orexigenic neuropeptides and activation of anorexigenic neuropeptides in the hypothalamus.
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影响因子：
3
作者：
Kuroda, K;Inoue, N;Fushiki, T
通讯作者：
Fushiki, T
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Matsukura, S