The effects of multivitamin supplementation on diurnal cortisol secretion and perceived stress.
The effects of multivitamin supplementation on diurnal cortisol secretion and perceived stress.
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DOI：
10.3390/nu5114429
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发表时间：
2013-11-11
期刊：
影响因子：
5.9
通讯作者：
Pipingas A
中科院分区：
文献类型：
--
作者：
Camfield DA;Wetherell MA;Scholey AB;Cox KH;Fogg E;White DJ;Sarris J;Kras M;Stough C;Sali A;Pipingas A
最近的证据表明，从饮食中摄入维生素，特别是b族维生素，包括B6、B9和B12，可能对情绪和压力有许多积极的影响。鉴于应激对包括内分泌系统在内的一系列生物机制的影响，我们可以合理地预期，补充多种维生素也可能影响这些机制的标志物，如昼夜皮质醇分泌。在目前的双盲安慰剂对照研究中，138名成年人（年龄在20至50岁之间）在16周的时间内服用含有b族维生素的复合维生素和安慰剂。在醒着、15分钟、30分钟和就寝时间、基线、8周和16周时测量唾液皮质醇。在基线、8周和16周测量感知应激（PSS），并在这些时间点收集血清B6、B12、同型半胱氨酸（HCy）和红细胞叶酸（B9）。在皮质醇唤醒反应（CAR）方面，治疗组与研究访视之间存在显著的相互作用。与安慰剂相比，在16周时，发现多种维生素补充剂与CAR增加的趋势接近显著相关。PSS在两组之间没有显著差异，在整个研究过程中，两组的PSS都在增加。研究发现，红细胞叶酸与16周时的CAR反应显著相关，而HCy水平与CAR反应不相关，尽管HCy与8周时的清醒皮质醇水平显著相关。CAR升高与补充多种维生素相关的一种可能解释是，这代表了健康参与者对日常需求的适应性反应。
Recent evidence suggests that dietary intake of vitamins, in particular the B-vitamins including B6, B9 and B12 may have a number of positive effects on mood and stress. Given the effects of stress on a range of biological mechanisms including the endocrine system, it could be reasonably expected that multivitamin supplementation may also affect markers of these mechanisms such as diurnal cortisol secretion. In the current double-blind placebo-controlled study 138 adults (aged 20 to 50 years) were administered a multivitamin containing B-vitamins versus placebo over a 16-week period. Salivary cortisol measurements were taken at waking, 15-min, 30-min and at bedtime, at baseline, 8-weeks and 16-weeks. Perceived Stress (PSS) was measured at baseline, 8-weeks and 16-weeks, while blood serum measures of B6, B12 and homocysteine (HCy) as well as red cell folate (B9) were also collected at these time points. A significant interaction was found between treatment group and study visit for the Cortisol Awakening Response (CAR). Compared to placebo, at 16-weeks multivitamin supplementation was found to be associated with a near-significant trend towards an increased CAR. No significant differences in PSS were found between groups, with PSS increasing in both groups across the course of the study. Red cell folate was found to be significantly correlated with the CAR response at 16-weeks while HCy levels were not found to be associated with the CAR response, although HCy significantly correlated with waking cortisol levels at 8-weeks. A possible interpretation of the elevation in CAR associated with multivitamin supplementation is that this represents an adaptive response to everyday demands in healthy participants.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.4
作者：
Kennedy, David O.;Veasey, Rachel;Watson, Anthony;Dodd, Fiona;Jones, Emma;Maggini, Silvia;Haskell, Crystal F.
通讯作者：
Haskell, Crystal F.
影响因子：
3.7
作者：
Kudielka, BM;Kirschbaum, C
通讯作者：
Kirschbaum, C
影响因子：
6.8
作者：
Berg, Anna L.;Rafnsson, Arnar T.;Arnadottir, Margret
通讯作者：
Arnadottir, Margret
影响因子：
3.7
作者：
Izawa, Shuhei;Saito, Keisuke;Nomura, Shinobu
通讯作者：
Nomura, Shinobu