Distinct epidemiological profiles associated with inflammatory breast cancer (IBC): A comprehensive analysis of the IBC registry at The University of Texas MD Anderson Cancer Center.
Distinct epidemiological profiles associated with inflammatory breast cancer (IBC): A comprehensive analysis of the IBC registry at The University of Texas MD Anderson Cancer Center.
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与炎性乳腺癌（IBC）相关的独特流行病学特征： 对德克萨斯大学 MD 安德森癌症中心 IBC 登记处的综合分析。
DOI：
10.1371/journal.pone.0204372
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
El-Zein R
中科院分区：
文献类型：
--
作者：
Fouad TM;Ueno NT;Yu RK;Ensor JE;Alvarez RH;Krishnamurthy S;Lucci A;Reuben JM;Yang W;Willey JS;Valero V;Bondy ML;Cristofinalli M;Shete S;Woodward WA;El-Zein R
迄今为止，关于炎性乳腺癌（IBC）的研究缺乏全面的流行病学数据。我们分析了来自德克萨斯大学 MD 安德森癌症中心 IBC 登记处的详细前瞻性收集的临床和流行病学数据。 IBC 患者 (n = 248) 在 2006 年 11 月至 2013 年 4 月期间连续诊断并前瞻性入组。所有患者均为新诊断且年龄至少 18 岁。次级 IBC 被排除在外。总共收集并评估了 160 个变量，包括社会人口统计学、人体测量学、烟草和酒精消费、生殖变量和家族史数据。诊断时的平均年龄为 51.6 (±11.5 SD) 岁，大多数患者是白人 (77.8%)。无论绝经状态如何，80.2% 的患者平均 BMI ≥ 25 kg/m2，其中 82.6% 的非裔美国人肥胖。大约 42.2% 的患者曾经吸烟，91% 的患者报告曾经怀孕过。据报告，54% 的患者有母乳喂养史，不同种族之间存在显着差异，白人女性更受青睐（P<0.0001）。与其他族裔群体相比，其他生殖因素（例如使用避孕药和激素替代疗法）也更频繁地与白人女性相关（P < 0.05）。在多变量 Cox 比例风险分析中，非裔美国人或西班牙裔、未母乳喂养、较高的临床分期和 TNBC 亚型与较短的生存期相关。我们的数据表明 IBC 与不同的流行病学特征相关。这些信息可以帮助根据患者可改变的行为模式制定特定的预防策略。
To date, studies on inflammatory breast cancer (IBC) lack comprehensive epidemiological data. We analyzed detailed prospectively collected clinical and epidemiological data from the IBC Registry at The University of Texas MD Anderson Cancer Center. Patients with IBC (n = 248) were consecutively diagnosed and prospectively enrolled between November 2006 and April 2013. All patients were newly diagnosed and at least 18 years old. Secondary IBC was excluded. Overall 160 variables were collected and evaluated including sociodemographics, anthropometrics, tobacco and alcohol consumption, reproductive variables, and family history data. Mean age at diagnosis was 51.6 (±11.5 SD) years, and the majority of patients were White (77.8%). A mean BMI ≥ 25 kg/m2, irrespective of menopausal status, was observed in 80.2% of all patients, with 82.6% of African Americans being obese. Approximately 42.2% of patients were ever smokers, and 91% reported ever being pregnant. A history of breastfeeding was reported in 54% of patients, with significant differences between ethnic groups in favor of White women (P<0.0001). Other reproductive factors such as use of birth control pills & hormone replacement therapy were also more frequently associated with White women compare to other ethnic groups (P < 0.05). In the multivariate Cox proportional hazard analysis, African American or Hispanic ethnicity, not having breastfed, higher clinical stage, and TNBC subtype were associated with shorter survival. Our data suggest that IBC is associated with distinct epidemiological profiles. This information could assist in targeting patients with specific preventive strategies based on their modifiable behavioral patterns.
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DOI：
10.1186/s41021-016-0071-7
发表时间：
2017
期刊：
Genes and environment : the official journal of the Japanese Environmental Mutagen Society
影响因子：
--
作者：
Yasuda MT;Sakakibara H;Shimoi K
通讯作者：
Shimoi K
影响因子：
5
作者：
van den Brandt, PA;Spiegelman, D;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
10.3
作者：
Hance, KW;Anderson, WF;Levine, PH
通讯作者：
Levine, PH
DOI：
10.1186/bcr2578
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
McCready J;Arendt LM;Rudnick JA;Kuperwasser C
通讯作者：
Kuperwasser C
影响因子：
3.8
作者：
Fouad, Tamer M.;Kogawa, Takahiro;Liu, Diane D.;Shen, Yu;Masuda, Hiroko;El-Zein, Randa;Woodward, Wendy A.;Chavez-MacGregor, Mariana;Alvarez, Ricardo H.;Arun, Banu;Lucci, Anthony;Krishnamurthy, Savitri;Babiera, Gildy;Buchholz, Thomas A.;Valero, Vicente;Ueno, Naoto T.
通讯作者：
Ueno, Naoto T.