Ciliary control of adipocyte progenitor cell fate regulates energy storage.

Ciliary control of adipocyte progenitor cell fate regulates energy storage.
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DOI:
10.3389/fcell.2022.1083372
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发表时间:
2022
影响因子:
5.5
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
作者:

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初级纤毛是一种细胞感觉器,存在于我们身体的大多数细胞中。这包括我们脂肪组织中的脂肪祖细胞,脂肪组织是一个复杂的器官,参与能量储存,内分泌信号和产热。大量研究表明,在多种脂肪组织类型中,初级纤毛在指导脂肪细胞祖细胞的细胞命运中起关键作用。因此,具有纤毛功能障碍的疾病称为纤毛病,具有广泛的临床表现,包括肥胖症和糖尿病。这篇综述总结了我们目前对初级纤毛如何在多种情况下调节脂肪祖细胞命运的理解,并说明了初级纤毛在调节能量储存和脂肪组织功能中的重要性。
The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis. Numerous studies have shown that the primary cilium plays a critical role in directing the cell fate of adipocyte progenitor cells in multiple adipose tissue types. Accordingly, diseases with dysfunctional cilia called ciliopathies have a broad range of clinical manifestations, including obesity and diabetes. This review summarizes our current understanding of how the primary cilium regulates adipocyte progenitor cell fate in multiple contexts and illustrates the importance of the primary cilium in regulating energy storage and adipose tissue function.
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