Influence of the hypothalamic arcuate nucleus on intraocular pressure and the role of opioid peptides.
Influence of the hypothalamic arcuate nucleus on intraocular pressure and the role of opioid peptides.
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下丘脑弓状核对眼压的影响及阿片肽的作用
DOI：
10.1371/journal.pone.0082315
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yuan ZL
中科院分区：
文献类型：
--
作者：
Jin J;Xu GX;Yuan ZL
背景：阿片肽神经元/体液反馈调节可能参与眼压的变化。本研究旨在探讨弓状核（ARC）和阿片肽对眼内压（IOP）的影响。方法健康纯种新西兰白色兔54只（108眼），随机分为4组：对照组、电刺激组、[D-Ala 2，N-Me-Phe 4，Gly 5-ol]-脑啡肽（DAMGO）组和[D-Pen 2，D-Pen 5]-脑啡肽（DPDPE）组。在单侧电刺激ARC或单侧微量注射选择性μ阿片受体激动剂DAMGO或选择性δ阿片受体激动剂DPDPE后测量双侧IOP，单独使用或预先给予非选择性阿片受体拮抗剂纳洛酮或生理盐水后。结果电刺激ARC和微量注射阿片受体激动剂DAMGO或DPDPE均可使双侧眼压显著降低（P<0.05），且同侧眼压较对侧更为显著。纳洛酮预处理阻止了部分但非全部IOP降低。结论ARC参与了眼压的负性调节，这一作用可能涉及阿片神经元。
Background An opioid peptide neuron/humoral feedback regulation might be involved in changes of intraocular pressure (IOP). The aims of this study are to investigate the effects of arcuate nucleus (ARC) and opioid peptides on intraocular pressure (IOP). Methods Fifty-four healthy purebred New Zealand white rabbits (108eyes) were randomly divided into 4 groups, including control group, electrical stimulation group, [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO) group, and [D-Pen 2, D-Pen5]- enkephalin (DPDPE) group. Bilateral IOP was measured after unilateral electrical stimulation of the ARC or unilateral microinjection into the ARC of the selective μ-opioid receptor agonist DAMGO or the selective δ opioid receptor agonist DPDPE, both alone and after pre-administration of either the non-selective opioid receptor antagonist naloxone or saline. Results Both electrical stimulation in ARC and micro-injection either or opioid receptor agonists, DAMGO or DPDPE, respectively, caused a significant bilateral reduction in IOP (P<0.05) which was more pronounced in the ipsilateral than in the contralateral eye. Pretreatment with naloxone prevented some, but not all IOP reductions. Conclusion The ARC takes part in the negative regulation of IOP, an action that may involve opioid neurons.
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影响因子：
3.6
作者：
DRAGO, F;GORGONE, G;SCAPAGNINI, U
通讯作者：
SCAPAGNINI, U
影响因子：
2.5
作者：
Ludwig, M;Leng, G
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影响因子：
2.1
作者：
ROHDE, BH;ZHU, M;CHIOU, GCY
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CHIOU, GCY
影响因子：
3.1
作者：
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通讯作者：
Russell, Karen R. M.
影响因子：
2.5
作者：
Fuxe, K;Tinner, B;Agnati, LF
通讯作者：
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