Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain.
Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain.
复制标题
DOI：
10.3389/fnana.2017.00128
复制
发表时间：
2017
影响因子：
2.9
通讯作者：
Gong H
中科院分区：
文献类型：
--
作者：
Xiong B;Li A;Lou Y;Chen S;Long B;Peng J;Yang Z;Xu T;Yang X;Li X;Jiang T;Luo Q;Gong H
理解令人惊讶的复杂脑功能和病理需要一个完整的脑血管立体定位坐标图谱。制作精确的脑动脉和静脉图谱是神经科学和神经病理学一个世纪以来的目标。使用显微光学断层扫描（MOST）与改进的尼氏染色方法，我们获得了五个小鼠脑数据集，包含动脉，静脉和微血管。基于小鼠全脑血管的空间结构和细胞构筑学所指示的脑区，我们首次构建并注释了小鼠全脑动脉和静脉血管系统图谱。结果表明，不同脑区血管的分布模式不同。微血管网络的重建和统计分析，包括定量血管密度的推导，表明不同脑区的血管直径主要在小于8 μm和大于20 μm的血管中存在显著差异。我们精确的脑血管图谱为脑功能和疾病的定量研究提供了重要的资源和方法。
Understanding amazingly complex brain functions and pathologies requires a complete cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral arteries and veins has been a century-old objective in neuroscience and neuropathology. Using micro-optical sectioning tomography (MOST) with a modified Nissl staining method, we acquired five mouse brain data sets containing arteries, veins, and microvessels. Based on the brain-wide vascular spatial structures and brain regions indicated by cytoarchitecture in one and the same mouse brain, we reconstructed and annotated the vascular system atlas of both arteries and veins of the whole mouse brain for the first time. The distributing patterns of the vascular system within the brain regions were acquired and our results show that the patterns of individual vessels are different from each other. Reconstruction and statistical analysis of the microvascular network, including derivation of quantitative vascular densities, indicate significant differences mainly in vessels with diameters less than 8 μm and large than 20 μm across different brain regions. Our precise cerebral vascular atlas provides an important resource and approach for quantitative studies of brain functions and diseases.
登录
查看更多内容
影响因子：
5.7
作者：
Dorr, A.;Sled, J. G.;Kabani, N.
通讯作者：
Kabani, N.
影响因子：
3
作者：
Cannon, RC;Turner, DA;Wheal, HV
通讯作者：
Wheal, HV
自动去除小鼠全脑尼氏染色显微图谱中的宏观密度伪影
影响因子：
2
作者：
Ding, W.;Li, A.;Gong, H.
通讯作者：
Gong, H.
影响因子：
25
作者：
Blinder, Pablo;Tsai, Philbert S.;Kaufhold, John P.;Knutsen, Per M.;Suhl, Harry;Kleinfeld, David
通讯作者：
Kleinfeld, David
微光学断层扫描获得小鼠大脑的高分辨率图谱
影响因子：
56.9
作者：
Li, Anan;Gong, Hui;Luo, Qingming
通讯作者：
Luo, Qingming