Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.
Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.
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DOI：
10.1096/fba.2020-00079
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发表时间：
2021-01
影响因子：
2.7
通讯作者：
Neufer PD
中科院分区：
文献类型：
--
作者：
Murashov AK;Pak ES;Lin CT;Boykov IN;Buddo KA;Mar J;Bhat KM;Neufer PD
高饱和脂肪、糖和盐含量是西方饮食（WD）的主要成分，导致肥胖、代谢综合征和其他过多的健康风险。然而，这些成分的组合效果尚未得到充分评价。在这里，使用野生捕获的模拟果蝇，我们表明富含饱和脂肪，糖和盐的饮食比单独使用每种成分更有害，导致寿命，运动活动，睡眠，生殖功能和线粒体功能显着减少。这些有害影响对雌性苍蝇的影响比对雄性苍蝇的影响更明显。在WD上增加定期飞行练习可以显着消除WD的不良影响。在分子水平上，WD显著增加了甘油三酯水平，并导致线粒体功能障碍，而运动抵消了这些影响。有趣的是，果蝇在预暴露后对WD产生了偏好，这是通过飞行运动避免的。结果表明，定期有氧运动可以减轻不利的饮食对果蝇线粒体功能，生理和摄食行为的影响。我们的数据建立了果蝇模拟作为饮食运动相互作用的新模型，与人类肥胖和饮食失调的病理生理学非常相似。
High saturated fat, sugar, and salt contents are a staple of a Western diet (WD), contributing to obesity, metabolic syndrome, and a plethora of other health risks. However, the combinatorial effects of these ingredients have not been fully evaluated. Here, using the wild‐caught Drosophila simulans, we show that a diet enriched with saturated fat, sugar, and salt is more detrimental than each ingredient separately, resulting in a significantly decreased lifespan, locomotor activity, sleep, reproductive function, and mitochondrial function. These detrimental effects were more pronounced in female than in male flies. Adding regular flight exercise to flies on the WD markedly negated the adverse effects of a WD. At the molecular level, the WD significantly increased levels of triglycerides and caused mitochondrial dysfunction, while exercise counterbalanced these effects. Interestingly, fruit flies developed a preference for the WD after pre‐exposure, which was averted by flight exercise. The results demonstrate that regular aerobic exercise can mitigate adverse dietary effects on fly mitochondrial function, physiology, and feeding behavior. Our data establish Drosophila simulans as a novel model of diet‐exercise interaction that bears a strong similarity to the pathophysiology of obesity and eating disorders in humans.
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影响因子：
9.2
作者：
Jiao, Yuchen;Moon, Seok Jun;Wang, Xiaoyue;Ren, Qiuting;Montell, Craig
通讯作者：
Montell, Craig
影响因子：
4
作者：
Drenowatz C;Sui X;Fritz S;Lavie CJ;Beattie PF;Church TS;Blair SN
通讯作者：
Blair SN
影响因子：
8.1
作者：
Heinrichsen ET;Zhang H;Robinson JE;Ngo J;Diop S;Bodmer R;Joiner WJ;Metallo CM;Haddad GG
通讯作者：
Haddad GG
影响因子：
4
作者：
de Paula, Mariane T.;Silva, Marcia R. P.;Prigol, Marina
通讯作者：
Prigol, Marina
影响因子：
3.7
作者：
Dmitrieva, A. S.;Ivnitsky, S. B.;Markov, A., V
通讯作者：
Markov, A., V