Estradiol and cognitive function: past, present and future.
Estradiol and cognitive function: past, present and future.
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DOI：
10.1016/j.yhbeh.2014.08.011
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发表时间：
2014-09
影响因子：
3.5
通讯作者：
Luine, Victoria N.
中科院分区：
文献类型：
--
作者：
Luine, Victoria N.
对雌激素增强认知功能的历史观点进行了介绍，并对主要在动物和人类身上进行的研究进行了综述。讨论了有关增强的潜在机制的数据。综述了雌激素通过膜相互作用和激活细胞间信号通路在记忆巩固中的快速作用的最新研究，以及集中在传统基因组机制的研究。讨论了最近神经元内雌二醇合成的证明以及作为神经类固醇促进记忆的可能作用。这一信息被应用于目前缺乏有效的激素(或其他)治疗与更年期和衰老相关的认知衰退的关键问题上。最后，讨论了雌激素效应的临界期假说以及激素/药物开发的新策略。总体而言，历史记录证明雌二醇对认知功能的某些方面有积极影响，但使用这种激素的有效治疗干预尚未实现。
A historical perspective on estradiol’s enhancement of cognitive function is presented, and research, primarily in animals, but also in humans, is reviewed. Data regarding the mechanisms underlying the enhancements are discussed. Newer studies showing rapid effects of estradiol on consolidation of memory through membrane interactions and activation of inter-cellular signaling pathways are reviewed as well as studies focused on traditional genomic mechanisms. Recent demonstrations of intra-neuronal estradiol synthesis and possible actions as a neurosteroid to promote memory are discussed. This information is applied to the critical issue of the current lack of effective hormonal (or other) treatments for cognitive decline associated with menopause and aging. Finally, the critical period hypothesis for estradiol effects is discussed along with novel strategies for hormone/drug development. Overall, the historical record documents that estradiol positively impacts some aspects of cognitive function, but effective therapeutic interventions using this hormone have yet to be realized.
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影响因子：
3.5
作者：
Aenlle, Kristina K.;Foster, Thomas C.
通讯作者：
Foster, Thomas C.
DOI：
10.1177/1073858413519865
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bean LA;Ianov L;Foster TC
通讯作者：
Foster TC
影响因子：
2.9
作者：
Beck, KD;Luine, VN
通讯作者：
Luine, VN
影响因子：
4.2
作者：
Bimonte, HA;Nelson, ME;Granholm, ACE
通讯作者：
Granholm, ACE
影响因子：
1.9
作者：
AGGLETON, JP;BLINDT, HS;CANDY, JM
通讯作者：
CANDY, JM