Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the power study.
Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the power study.
复制标题
DOI：
10.1371/journal.pone.0028912
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
P.O.W.E.R. (Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression) Study Group
中科院分区：
文献类型：
--
作者：
Cizza G;Ronsaville DS;Kleitz H;Eskandari F;Mistry S;Torvik S;Sonbolian N;Reynolds JC;Blackman MR;Gold PW;Martinez PE;P.O.W.E.R. (Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression) Study Group
重度抑郁症 (MDD) 与不良医疗后果有关，包括心血管疾病和骨质疏松症。 MDD 患者可分为忧郁型、非典型型或未分化型特征。本研究的目的是评估这些抑郁症的临床亚型是否具有不同的内分泌和代谢特征，从而导致不同的医疗结果。招募年龄 21 至 45 岁、患有 MDD 的绝经前女性 (N = 89) 和健康对照者 (N = 44) 进行骨转换的前瞻性研究。患有MDD的女性被分为具有忧郁（N = 51）、非典型（N = 16）或未分化（N = 22）特征。结果测量包括：代谢参数、身体成分、骨矿物质密度 (BMD) 以及血浆促肾上腺皮质激素 (ACTH)、皮质醇和瘦素的 24 小时采样。与对照组相比，具有未分化和非典型MDD特征的女性表现出更大的BMI、腰臀比以及全身和腹部脂肪量。与对照组相比，具有未分化 MDD 特征的女性除了股骨颈低 BMD 的患病率更高外，血脂和空腹血糖水平也较高。在具有非典型抑郁症特征的女性中，ACTH 水平升高，而在忧郁亚组中观察到平均 24 小时瘦素水平较高。具有各种 MDD 特征的绝经前女性表现出代谢、内分泌和 BMD 特征，这些特征可能与不同的健康后果相关。 ClinicalTrials.gov NCT00006180
Major depressive disorder (MDD) has been associated with adverse medical consequences, including cardiovascular disease and osteoporosis. Patients with MDD may be classified as having melancholic, atypical, or undifferentiated features. The goal of the present study was to assess whether these clinical subtypes of depression have different endocrine and metabolic features and consequently, varying medical outcomes. Premenopausal women, ages 21 to 45 years, with MDD (N = 89) and healthy controls (N = 44) were recruited for a prospective study of bone turnover. Women with MDD were classified as having melancholic (N = 51), atypical (N = 16), or undifferentiated (N = 22) features. Outcome measures included: metabolic parameters, body composition, bone mineral density (BMD), and 24 hourly sampling of plasma adrenocorticotropin (ACTH), cortisol, and leptin. Compared with control subjects, women with undifferentiated and atypical features of MDD exhibited greater BMI, waist/hip ratio, and whole body and abdominal fat mass. Women with undifferentiated MDD characteristics also had higher lipid and fasting glucose levels in addition to a greater prevalence of low BMD at the femoral neck compared to controls. Elevated ACTH levels were demonstrated in women with atypical features of depression, whereas higher mean 24-hour leptin levels were observed in the melancholic subgroup. Pre-menopausal women with various features of MDD exhibit metabolic, endocrine, and BMD features that may be associated with different health consequences. ClinicalTrials.gov NCT00006180
登录
查看更多内容
影响因子：
16.2
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
通讯作者：
Elmquist, JK
影响因子：
11.3
作者：
Benazzi, F
通讯作者：
Benazzi, F
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
11
作者：
Anisman, H;Ravindran, AV;Merali, Z
通讯作者：
Merali, Z
影响因子：
--
作者：
Eskandari, Farideh;Martinez, Pedro E.;Cizza, Giovanni
通讯作者：
Cizza, Giovanni