Combined KHFAC + DC nerve block without onset or reduced nerve conductivity after block.
Combined KHFAC + DC nerve block without onset or reduced nerve conductivity after block.
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DOI：
10.1088/1741-2560/11/5/056012
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发表时间：
2014-10
影响因子：
4
通讯作者：
Kilgore K
中科院分区：
文献类型：
--
作者：
Franke M;Vrabec T;Wainright J;Bhadra N;Bhadra N;Kilgore K
千赫兹频率交流波形 (KHFAC) 已被证明可以在许多急性和慢性动物模型中提供周围神经传导阻滞。 KHFAC 神经阻滞可用于解决由神经过度活动引起的多种疾病，包括缓解疼痛和痉挛。然而，KHFAC 阻滞的一个缺点是神经阻滞启动期间神经纤维的短暂激活，称为起始反应。本研究的目的是评估使用电荷平衡直流 (CBDC) 波形暂时阻断 KHFAC 电极远端运动神经传导以减轻阻断起始反应的可行性。本研究中总共使用了八只动物。使用一组四只动物来评估组合 KHFAC+CBDC 块的可行性和再现性。以下对第二组四只动物进行的随机研究比较了单独使用 KHFAC 和组合 KHFAC+CBDC 波形产生的起效反应。为了量化起效，在 KHFAC 阻滞启动过程中测量了峰值力和力-时间积分。在整个研究过程中，通过比较块电极近端和远端的超最大刺激引起的肌肉抽搐力来监测神经传导性。随机研究的每只动物接受至少 300 秒（范围：318 至 1563 秒）的累积 DC，以研究 KHFAC+CBDC 组合对神经活力的影响。峰值起始力从单独使用 KHFAC 的 20.73 N（范围：18.6–26.5 N）显着降低至使用 CBDC 和 KHFAC 块波形组合的 0.45 N（范围：0.2–0.7 N）（p<0.001）。力曲线下面积从 6.8 Ns（范围：3.5–21.9 Ns）减少到 0.54 Ns（范围：0.18–0.86 Ns）（p<0.01）。在应用组合 KHFAC+CBDC 阻滞后，相对于 KHFAC 波形，没有观察到神经电导率的变化。 CBDC 的远端应用可以在不改变神经传导性的情况下显着减少甚至完全阻止 KHFAC 发作反应。
Kilohertz Frequency Alternating Current waveforms (KHFAC) have been shown to provide peripheral nerve conductivity block in many acute and chronic animal models. KHFAC nerve block could be used to address multiple disorders caused by neural over-activity, including blocking pain and spasticity. However, one drawback of KHFAC block is a transient activation of nerve fibers during the initiation of the nerve block, called the onset response. The objective of this study is to evaluate the feasibility of using charge balanced direct current (CBDC) waveforms to temporarily block motor nerve conductivity distally to the KHFAC electrodes to mitigate the block onset-response. A total of eight animals were used in this study. A set of four animals were used to assess feasibility and reproducibility of a combined KHFAC+CBDC block. A following randomized study, conducted on a second set of four animals, compared the onset response resulting from KHFAC alone and combined KHFAC+CBDC waveforms. To quantify the onset, peak forces and the force-time integral were measured during KHFAC block initiation. Nerve conductivity was monitored throughout the study by comparing muscle twitch forces evoked by supra-maximal stimulation proximal and distal to the block electrodes. Each animal of the randomized study received at least 300 seconds (range: 318 to 1563s) of cumulative DC to investigate the impact of combined KHFAC+CBDC on nerve viability. The peak onset force was reduced significantly from 20.73 N (range: 18.6–26.5 N) with KHFAC alone to 0.45 N (range: 0.2–0.7 N) with the combined CBDC and KHFAC block waveform (p<0.001). The area under the force curve was reduced from 6.8 Ns (range: 3.5–21.9 Ns) to 0.54 Ns (range: 0.18–0.86Ns) (p<0.01). No change in nerve conductivity was observed after application of the combined KHFAC+CBDC block relative to KHFAC waveforms. The distal application of CBDC can significantly reduce or even completely prevent the KHFAC onset response without a change in nerve conductivity.
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DOI：
10.1111/ner.12100
发表时间：
2014-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Kilgore KL;Bhadra N
通讯作者：
Bhadra N
影响因子：
3
作者：
Foldes, Emily L.;Ackermann, D. Michael;Bhadra, Niloy;Kilgore, Kevin L.;Bhadra, Narendra
通讯作者：
Bhadra, Narendra
影响因子：
4
作者：
Ackermann DM;Bhadra N;Gerges M;Thomas PJ
通讯作者：
Thomas PJ
影响因子：
2.8
作者：
Tiede, Jeffrey;Brown, Lora;Morgan, Donna
通讯作者：
Morgan, Donna
神经袖带电极几何形状对高频神经传导阻滞中起始反应放电的影响。
DOI：
10.1109/tnsre.2010.2071882
发表时间：
2010-12
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Ackermann DM Jr;Bhadra N;Foldes EL;Wang XF;Kilgore KL
通讯作者：
Kilgore KL