Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study.
Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study.
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53岁时膝关节骨关节炎的生命历程纵向增长和风险：来自1946年英国出生队列研究的证据
DOI：
10.1016/j.joca.2020.12.012
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发表时间：
2021-03
影响因子：
7
通讯作者：
Cooper R
中科院分区：
文献类型：
--
作者：
Staines KA;Hardy R;Samvelyan HJ;Ward KA;Cooper R
在MRC国家健康与发展调查（NSHD）中，检查儿童期和青少年期身高增加与膝关节骨关节炎之间的关系。数据来自NSHD的3035名男性和女性参与者。在2岁、4岁、6岁、7岁、11岁和15岁时测量身高，并在20岁时自我报告。测试了（1）每个年龄的身高（2）特定生命周期内的身高增长（3）身高尺寸、克里思和速度的平移和旋转叠加（SITAR）生长曲线变量与53岁时膝关节骨关节炎之间的关系。在性别调整模型中，在所有年龄段，身高较高与53岁时膝关节骨关节炎几率降低之间的估计相关性都很小-最大的相关性是4岁时身高每增加5 cm，膝关节骨关节炎的OR为0.9，（95% CI 0.7-1.1），6岁时身高每增加5 cm，OR为0.9（95% CI 0.8-1.0）。在特定的生命周期内身高增加或SITAR生长曲线变量与膝关节骨关节炎的几率之间没有发现相关性。有有限的证据表明，在该队列中，儿童期较高的身高与53岁时膝关节骨关节炎的几率降低有关。这项工作增强了我们对骨关节炎易感性的理解，以及生命历程高度对此的贡献。
To examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in the MRC National Survey of Health and Development (NSHD). Data are from 3035 male and female participants of the NSHD. Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at ages 20 years. Associations between (1) height at each age (2) height gain during specific life periods (3) Super-Imposition by Translation And Rotation (SITAR) growth curve variables of height size, tempo and velocity, and knee osteoarthritis at 53 years were tested. In sex-adjusted models, estimated associations between taller height and decreased odds of knee osteoarthritis at age 53 years were small at all ages - the largest associations were an OR of knee osteoarthritis of 0.9 per 5 cm increase in height at age 4, (95% CI 0.7–1.1) and an OR of 0.9 per 5 cm increase in height, (95% CI 0.8–1.0) at age 6. No associations were found between height gain during specific life periods or the SITAR growth curve variables and odds of knee osteoarthritis. There was limited evidence to suggest that taller height in childhood is associated with decreased odds of knee osteoarthritis at age 53 years in this cohort. This work enhances our understanding of osteoarthritis predisposition and the contribution of life course height to this.
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影响因子：
7.7
作者：
Cole TJ;Donaldson MD;Ben-Shlomo Y
通讯作者：
Ben-Shlomo Y
影响因子：
4.9
作者：
Wills, Andrew K.;Hardy, Rebecca J.;Kuh, Diana J.
通讯作者：
Kuh, Diana J.
DOI：
10.1017/s2040174414000373
发表时间：
2014-12
影响因子：
1.7
作者：
Clynes MA;Parsons C;Edwards MH;Jameson KA;Harvey NC;Sayer AA;Cooper C;Dennison EM
通讯作者：
Dennison EM
影响因子：
27.4
作者：
Wills AK;Black S;Cooper R;Coppack RJ;Hardy R;Martin KR;Cooper C;Kuh D
通讯作者：
Kuh D
影响因子：
7.7
作者：
Cole, T. J.;Kuh, D.;Ong, K. K.
通讯作者：
Ong, K. K.