Changes in the prevalence of hyperuricemia in clients of health examination in Eastern China, 2009 to 2019.
Changes in the prevalence of hyperuricemia in clients of health examination in Eastern China, 2009 to 2019.
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DOI：
10.1186/s12902-022-01118-z
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发表时间：
2022-08-10
影响因子：
2.7
通讯作者：
Zhang, Zhenwen
中科院分区：
文献类型：
--
作者：
She, Dunmin;Wang, Yongliang;Liu, Jing;Luo, Na;Feng, Shangyong;Li, Ying;Xu, Jin;Xie, Shichun;Zhu, Yan;Xue, Ying;Zhang, Zhenwen
随着人们生活水平的不断提高，高尿酸血症的发病率在全球范围内呈上升趋势。华裔的患病率因地区、种族和年龄的不同而不同。本研究旨在调查2009年至2019年间东区中国地区体检人群华侨华人患病率的变化。入选年龄20-79岁的中国男性和女性(2009年组n = 4847,2019年组n = 12,188)，接受健康检查。测定血尿酸(UA)水平及空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、肌酐(Cr)、血尿素氮(BUN)。测定不同年龄段HUA患病率，并分析生化指标与HUA的相关性。2019年人群华华患病率为18.7%，明显高于2009年的11.1%。在女性中，2019年20-29岁和30-39岁年龄组的华华患病率明显高于2009年。在男性人群中，2019年参与者在所有年龄组中的特定年龄患病率显著高于2009年参与者。在2019年的参与者中，20-29岁的年轻男性成为华语的主要人群，而在2009年的参与者中，40-49岁的中年男性的华语患病率最高。2019年受试者各BMI组的HUA患病率均显著高于2009年受试者。相关分析和Logistic回归分析表明，BMI与HUA呈正相关。受试者-操作特征曲线分析显示，2009年和2019年的受试者中，体重指数 >； 分别为24.48g/m2和23.84g/m2， >； 分别为23.84g/m2和23.84g/m2。近10年来，华侨华人在中国成年人中的患病率迅速上升，特别是在男性中。2019年，年轻男性群体(20-29岁)在2009年取代中年男性群体(40-49岁)，成为男华的领先年龄段。BMI与HUA呈正相关，可能是预测HUA的潜在危险因素。
With the continuous improvement of people's living standards, the incidence of hyperuricemia (HUA) is increasing globally. The prevalence of HUA ranged in terms of region, race, and age. This study aims to investigate the changes in the prevalence of HUA in clients of health examination in Eastern China between 2009 and 2019. Chinese men and women aged 20–79 years (n = 4847 in the 2009 group and n = 12,188 in 2019 group) who had received health examinations were enrolled. Serum uric acid (UA) levels and biochemical parameters, including fasting blood-glucose (FBG), triglyceride (TG), total cholesterol (CHOL), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr) and blood urea nitrogen (BUN) were evaluated. The prevalence of HUA in different age groups were measured, and the correlation of biochemical parameters with HUA were analyzed. The prevalence of HUA was 18.7% in the 2019 group, which was significantly higher than that in 2009 (11.1%). In females, the prevalence of HUA was significantly higher in 2019 than 2009 for age groups of 20–29 and 30–39 years. In male population, 2019 participants had significantly higher age-specific prevalence for all age groups than 2009 participants. Young men aged 20–29 years became the main population of HUA in the 2019 participants, whereas middle-aged men aged 40–49 years had the highest prevalence of HUA in the 2009 participants. The prevalence rates of HUA in all BMI groups in 2019 participants were significantly higher than those in 2009 participants. Spearmen’s correlation analysis and Logistic regression analysis indicated that BMI was positively correlated with HUA. The receiver-operating characteristic curve (ROC) analysis showed BMI > 24.48 kg/m2 and BMI > 23.84 kg/m2 displayed good capacities to discriminate the population with HUA from those without HUA in 2009 and 2019 participants, respectively. In recent 10 years, the prevalence of HUA was increased rapidly in Chinese adults, especially in males. In 2019, the young male group (20–29 years old) replaced the middle-aged male group (40–49 years old) in 2009 as the leading age group for male HUA. BMI was positively correlated with HUA, and might be a potential risk factors to predict HUA.
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