Bilateral Subdiaphragmatic Vagal Nerve Stimulation Using a Novel Waveform Decreases Body Weight, Food Consumption, Adiposity, and Activity in Obesity-Prone Rats.
Bilateral Subdiaphragmatic Vagal Nerve Stimulation Using a Novel Waveform Decreases Body Weight, Food Consumption, Adiposity, and Activity in Obesity-Prone Rats.
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DOI：
10.1007/s11695-023-06957-w
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发表时间：
2024-01
期刊：
影响因子：
2.9
通讯作者：
Schiefer, Matthew A.
中科院分区：
文献类型：
--
作者：
Leinen, Monique;Grandy, Elise F.;Gebel, Lourdes M. Ubeira;Santana, Tahimi Machin;Rodriguez, Amanda L.;Singh, Sundip K.;Fernandez, Michael I.;Dalugdug, Justin C.;Garcia-Colon, Elaine M.;Lybeshari, Kamela;Alexander, Daniel R.;Maura, Maria I.;Gonzalez, Maria D. Cabrera;De Paula Cunha Almeida, Caroline;Anyaso-Samuel, Samuel;Datta, Somnath;Schiefer, Matthew A.
肥胖影响着数百万美国人。迷走神经通过内脏纤维传入将胃的饱足程度传递给大脑。研究发现迷走神经刺激（VNS）促进减少食物摄入，导致体重减轻，并减少渴望和食欲。在这里，我们评估了一种新的刺激波形应用于双侧膈下迷走神经刺激（sVNS）近13周的效果。在高脂肪饮食的易肥胖大鼠中植入刺激袖带电极。研究人员对体重、食物消耗和日常活动进行了长期跟踪，并与三个对照组进行了比较：高脂肪饮食的假大鼠被植入了非手术手铐，高脂肪饮食的大鼠没有被植入，标准饮食的大鼠没有被植入。结果显示，接受sVNS的高脂肪饮食大鼠与标准饮食大鼠的体重相似，主要是由于每日热量摄入减少。高脂肪饮食的大鼠接受sVNS治疗后，体脂明显少于其他高脂肪对照组。接受sVNS的大鼠也开始移动与标准饮食的大鼠相似的量。本研究结果表明，双侧膈下迷走神经刺激可以通过减少每日热量摄入来改变高脂肪饮食大鼠的生长速度，使其体重在大约13周内恢复到与标准饮食大鼠相似的体重。在线版本包含补充材料，可在10.1007/s11695-023-06957-w获得。
Obesity affects millions of Americans. The vagal nerves convey the degree of stomach fullness to the brain via afferent visceral fibers. Studies have found that vagal nerve stimulation (VNS) promotes reduced food intake, causes weight loss, and reduces cravings and appetite. Here, we evaluate the efficacy of a novel stimulus waveform applied bilaterally to the subdiaphragmatic vagal nerve stimulation (sVNS) for almost 13 weeks. A stimulating cuff electrode was implanted in obesity-prone Sprague Dawley rats maintained on a high-fat diet. Body weight, food consumption, and daily movement were tracked over time and compared against three control groups: sham rats on a high-fat diet that were implanted with non-operational cuffs, rats on a high-fat diet that were not implanted, and rats on a standard diet that were not implanted. Results showed that rats on a high-fat diet that received sVNS attained a similar weight to rats on a standard diet due primarily to a reduction in daily caloric intake. Rats on a high-fat diet that received sVNS had significantly less body fat than other high-fat controls. Rats receiving sVNS also began moving a similar amount to rats on the standard diet. Results from this study suggest that bilateral subdiaphragmatic vagal nerve stimulation can alter the rate of growth of rats maintained on a high-fat diet through a reduction in daily caloric intake, returning their body weight to that which is similar to rats on a standard diet over approximately 13 weeks. The online version contains supplementary material available at 10.1007/s11695-023-06957-w.
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影响因子：
2.9
作者：
Pelot NA;Grill WM
通讯作者：
Grill WM
影响因子：
2.8
作者：
Diaz-Gueemes, Idoia;Sanchez, Francisco M.;Uson, Jesus
通讯作者：
Uson, Jesus
影响因子：
3.7
作者：
Banni S;Carta G;Murru E;Cordeddu L;Giordano E;Marrosu F;Puligheddu M;Floris G;Asuni GP;Cappai AL;Deriu S;Follesa P
通讯作者：
Follesa P
影响因子：
4.5
作者：
FALEMPIN, M;MEI, N;ROUSSEAU, JP
通讯作者：
ROUSSEAU, JP
影响因子：
2.6
作者：
Koren, MS;Holmes, MD
通讯作者：
Holmes, MD