Comparative Analysis of Transcriptional Regulation Patterns: Understanding the Gene Expression Profile in Nucleocytoviricota.
Comparative Analysis of Transcriptional Regulation Patterns: Understanding the Gene Expression Profile in Nucleocytoviricota.
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DOI：
10.3390/pathogens10080935
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发表时间：
2021-07-24
期刊：
影响因子：
--
通讯作者：
Rodrigues RAL
中科院分区：
文献类型：
--
作者：
de Souza FG;Abrahão JS;Rodrigues RAL
核胞质大DNA病毒（NCLDV）具有独特的特性，引起了科学界的关注，目前被归入核胞病毒门。它们的特点是共享许多基因，并有自己的转录装置，这提供了一定的独立性，不依赖于宿主的机制。因此，一个强大的转录装置的存在引起了关于这些病毒及其基因组进化方面的许多讨论。了解NCLDV的转录过程将提供有关其进化史的信息，并更好地理解这些病毒的生物学特性及其与宿主的相互作用。在这项工作中，我们回顾了NCLDV转录，并对六个不同病毒科的代表在不同感染时间表达的基因组进行了比较功能分析。通过这一分析，可以观察到它们基因表达的时间概况，以及在整个繁殖周期的特定阶段激活的一组基因，这是该群体的共同特征。由于缺乏关于这组病原体转录调控过程的信息，我们试图提供有助于并开辟其他属于核细胞病毒的病毒转录研究领域的信息。
The nucleocytoplasmic large DNA viruses (NCLDV) possess unique characteristics that have drawn the attention of the scientific community, and they are now classified in the phylum Nucleocytoviricota. They are characterized by sharing many genes and have their own transcriptional apparatus, which provides certain independence from their host’s machinery. Thus, the presence of a robust transcriptional apparatus has raised much discussion about the evolutionary aspects of these viruses and their genomes. Understanding the transcriptional process in NCLDV would provide information regarding their evolutionary history and a better comprehension of the biology of these viruses and their interaction with hosts. In this work, we reviewed NCLDV transcription and performed a comparative functional analysis of the groups of genes expressed at different times of infection of representatives of six different viral families of giant viruses. With this analysis, it was possible to observe a temporal profile of their gene expression and set of genes activated in specific phases throughout the multiplication cycle as a common characteristic of this group. Due to the lack of information regarding the transcriptional regulation process of this group of pathogens, we sought to provide information that contributes to and opens up the field for transcriptional studies of other viruses belonging to Nucleocytoviricota.
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DOI：
10.3390/v8110278
发表时间：
2016-10-28
期刊：
Viruses
影响因子：
--
作者：
Bajrai LH;Benamar S;Azhar EI;Robert C;Levasseur A;Raoult D;La Scola B
通讯作者：
La Scola B
影响因子：
5.2
作者：
Filée J
通讯作者：
Filée J
影响因子：
2.7
作者：
D'Costa, SM;Yao, HJ;Bilimoria, SL
通讯作者：
Bilimoria, SL
影响因子：
10.7
作者：
Allen, MJ;Schroeder, DC;Wilson, WH
通讯作者：
Wilson, WH
影响因子：
5.2
作者：
Andreani, Julien;Khalil, Jacques Y. B.;La Scola, Bernard
通讯作者：
La Scola, Bernard