Aberrant structural synaptic dynamics precede disorganization of temporal and spatial coding in the hippocampus upon repeated stress exposure
Aberrant structural synaptic dynamics precede disorganization of temporal and spatial coding in the hippocampus upon repeated stress exposure
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反复应激暴露后，异常的结构性突触动力学先于海马体的时间和空间编码混乱
DOI：
10.1101/2020.11.30.403972
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Alireza Chenani
中科院分区：
文献类型：
--
作者：
Alireza Chenani
应激暴露对精神疾病如抑郁症、精神分裂症、焦虑症和创伤后应激障碍的病理生理有重要影响。它还影响海马CA1的功能和结构，导致情景记忆障碍。本研究采用脑深部光学成像技术研究应激对CA1锥体神经元结构连通性和活性的影响。我们追踪了树突棘在反复压力下的动态变化，发现脊柱发生的减少伴随着脊柱稳定性的下降。与重复应激相反，急性应激导致在应激事件的时间附近出生的脊柱稳定。为了研究反复应力作用下结构可塑性与活动模式之间的联系，我们研究了数千个自由运动的CA1锥体神经元的活动。我们发现，随着时间和空间编码的中断，活动增加和时间组织的丧失。我们的数据表明，压力引起的活动持续增加导致结构连通性丧失和随后的时间和空间编码障碍。
Stress exposure strongly contributes to the pathophysiology of psychiatric diseases such as depression, schizophrenia, anxiety, and post-traumatic stress disorder. It also affects both function and structure of hippocampal CA1, leading to episodic memory impairment. Here, we used deep-brain optical imaging to elucidate the effects of stress on CA1 pyramidal neuron structural connectivity and activity.We tracked dynamics of dendritic spines during repeated stress and found decrease in spinogenesis followed by decrease in spine stability. In contrast to repeated stress, acute stress led to stabilization of the spines born in temporal proximity to the stressful event. To investigate the link between structural plasticity and activity patterns upon repeated stress, we studied the activity of thousands of CA1 pyramidal neurons in freely-moving. We found an increase in activity and loss of temporal organization followed by a disruption in temporal and spatial coding. Our data suggest that stress-induced sustained increase in activity leads to loss of structural connectivity and subsequent temporal and spatial coding impairments.
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影响因子：
1.2
作者：
Peyrache A;Benchenane K;Khamassi M;Wiener SI;Battaglia FP
通讯作者：
Battaglia FP
影响因子：
16.2
作者：
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通讯作者：
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DOI：
10.1038/nrn.2015.22
发表时间：
2016-02
期刊：
Nature reviews. Neuroscience
影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1210929109
发表时间：
2012-09
期刊：
Proceedings of the National Academy of Sciences
影响因子：
--
作者：
Csaba Varga;P. Golshani;I. Soltesz
通讯作者：
Csaba Varga;P. Golshani;I. Soltesz
影响因子：
8.8
作者：
Mizuseki K;Buzsáki G
通讯作者：
Buzsáki G