Selenium and mercury in the Brazilian Amazon: opposing influences on age-related cataracts.
Selenium and mercury in the Brazilian Amazon: opposing influences on age-related cataracts.
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DOI：
10.1289/ehp.0901284
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发表时间：
2010-11
影响因子：
10.4
通讯作者：
Mergler D
中科院分区：
文献类型：
--
作者：
Lemire M;Fillion M;Frenette B;Mayer A;Philibert A;Passos CJ;Guimarães JR;Barbosa FJ;Mergler D
糖尿病相关性白内障（ARC）是发展中国家致盲的重要原因。虽然抗氧化剂可能是身体防御的一部分，以防止ARC，环境污染物可能有助于白内障的发生。据报道，在塔帕霍斯下游地区的食鱼人群中，汞（Hg）暴露量增加，血液中硒（Se）水平从正常到非常高（> 1，000微克/升）不等。我们研究了12个滨江社区的成年人（≥ 40岁）与这些元素的ARC。参与者（n = 211）提供了血液样本，并进行了广泛的眼部检查。电感耦合等离子体质谱法用于评估汞和硒在血液和血浆中。三分之一（n = 69; 32.7%）的参与者患有ARC。低硒（P-Se;<25 th百分位数，110 μg/L）和血汞（B-Hg; ≥ 25 th百分位数，25 μg/L）与ARC的患病率比值比（POR）较高相关[校正后的POR（95%置信区间）分别为2.69（1.11-6.56）和4.45（1.43-13.83）]。在高硒磷的参与者中，我们观察到一个积极的，但不显着的关联与高硼汞暴露，而在那些低硼汞，我们没有观察到与硒磷。但与最佳条件（高磷硒、低硼汞）相比，低磷硒、高硼汞条件下的POR值为16.4（3.0-87.9）。这一发现表明存在协同效应。我们的研究结果表明，在这个人群中的人与汞升高，汞的白内障的影响可能会抵消硒。由于样本量相对较小且可能受到其他膳食营养素的混淆，需要进行具有足够功效来评估多种营养素和毒性相互作用的额外研究来证实这些发现。
Age-related cataracts (ARCs) are an important cause of blindness in developing countries. Although antioxidants may be part of the body’s defense to prevent ARC, environmental contaminants may contribute to cataractogenesis. In fish-eating populations of the lower Tapajós region, elevated exposure to mercury (Hg) has been reported, and blood levels of selenium (Se) range from normal to very high (> 1,000 μg/L). We examined ARCs in relation to these elements among adults (≥ 40 years of age) from 12 riverside communities. Participants (n = 211) provided blood samples and underwent an extensive ocular examination. Inductively coupled plasma mass spectrometry was used to assess Hg and Se in blood and plasma. One-third (n = 69; 32.7%) of the participants had ARC. Lower plasma Se (P-Se; < 25th percentile, 110 μg/L) and higher blood Hg (B-Hg; ≥ 25th percentile, 25 μg/L) were associated with a higher prevalence odds ratio (POR) of ARC [adjusted POR (95% confidence interval), 2.69 (1.11–6.56) and 4.45 (1.43–13.83), respectively]. Among participants with high P-Se, we observed a positive but nonsignificant association with high B-Hg exposure, whereas among those with low B-Hg, we observed no association for P-Se. However, compared with the optimum situation (high P-Se, low B-Hg), the POR for those with low P-Se and high B-Hg was 16.4 (3.0–87.9). This finding suggests a synergistic effect. Our results suggest that persons in this population with elevated Hg, the cataractogenic effects of Hg may be offset by Se. Because of the relatively small sample size and possible confounding by other dietary nutrients, additional studies with sufficient power to assess multiple nutrient and toxic interactions are required to confirm these findings.
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影响因子：
3.7
作者：
Fernandez, Mark M.;Afshari, Natalie A.
通讯作者：
Afshari, Natalie A.
影响因子：
--
作者：
Kyselova Z
通讯作者：
Kyselova Z
DOI：
10.1159/000082770
发表时间：
2005-01-01
期刊：
NUTRITION AND THE EYE: BASIC AND CLINICAL RESEARCH
影响因子：
--
作者：
Flohé, L
通讯作者：
Flohé, L
影响因子：
6.2
作者：
Batista, Bruno Lemos;Rodrigues, Jairo Lisboa;Barbosa, Fernando, Jr.
通讯作者：
Barbosa, Fernando, Jr.
影响因子：
3.8
作者：
Burk, RF;Norsworthy, BK;Byrne, DW
通讯作者：
Byrne, DW