Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model.
Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model.
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DOI：
10.1007/s10439-020-02575-0
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发表时间：
2021-01
影响因子：
3.8
通讯作者：
Haj-Ali R
中科院分区：
文献类型：
--
作者：
Morany A;Lavon K;Bluestein D;Hamdan A;Haj-Ali R
主动脉瓣（AV）位于左心室和主动脉之间，负责维持向外的单向血流。 AV 的许多血流动力学和结构方面已得到广泛研究，然而，需要更复杂的模型来更好地了解 AV 生物力学行为。本研究涉及将新的参数化 AV 结构模型与机电活体心脏人体模型® (LHHM) 相集成。 LHHM 是模拟人类心脏的有限元模型，能够进行真实的机电模拟。 AV 的不同几何指标已经被检验。由于 LHHM 派生出真实的边界条件，LHHM 内的新集成结构 AV 模型可以更好地预测心动周期期间的局部应力。研究发现，椭圆度指数 (EI)（计算为主动脉环 (AA) 最大 (Max) 和最小 (Min) 直径之间的比率）与接受计算机断层扫描 (CT) 的患者获得的测量临床数据密切相关，而环周长 (Perim) 也符合相同的趋势。这增加了对预测运动学行为、小叶接合和整体应力的信心。从临床方面来看，新提出的耦合集成 AV 模型可以作为设计和实施预经导管主动脉瓣置换术 (TAVR) 手术的平台。
The aortic valve (AV) is located between the left ventricle and the aorta and responsible for maintaining an outward unidirectional flow. Many AV hemodynamic and structural aspects of have been extensively studied, however, more sophisticated models are needed to better understand the AV biomechanical behavior. This study deals with integrating a new parametric AV structural model with the electro-mechanical Living Heart Human Model® (LHHM). The LHHM is a finite element model simulating human heart capable of realistic electro-mechanical simulations. Different geometric metrics of AV have been examined. New integrated structural AV model within the LHHM better predict local stresses during the cardiac cycle due to the realistic boundary condition derived from the LHHM. It was found that ellipticity index (EI), calculated as the ratio between the maximal (Max) and minimal (Min) aortic annulus (AA) diameters, well correlates with measured clinical data obtained from patients undergoing computed tomography (CT) while the annular perimeter (Perim) matches the same trend. This increases the confidence in the predicted kinematic behavior, leaflets coaptation, and the overall stresses. From the clinical aspect, the new proposed coupled and integrated AV modeling can serve as a platform for design and implementation of pre-transcatheter aortic valve replacement (TAVR) procedures.
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