The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013.
The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013.
复制标题
2013年中国登革热流行特征及传播动态
DOI：
10.1371/journal.pntd.0005095
复制
发表时间：
2016-11
影响因子：
3.8
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Sang S;Wang S;Lu L;Bi P;Lv M;Liu Q
背景2013年，我国多个地区发生登革热疫情。目前还没有研究探讨登革热在中国不同地理位置之间的传播动力学。目的分析2013年我国登革热流行特征，探讨登革热的传播动态。2013年登革热病例的方法和主要发现记录来自中国法定传染病监测系统。从GenBank中下载我国登革病毒E基因全序列。利用地理信息系统和热图描述流行病学特征。最大似然系统发育和贝叶斯地理分析，探讨登革热的动态传播。2013年疫情中，云南省和广东省的输入性病例最多。在有本地登革热传播的地方，大部分外地传入个案于2013年6月至11月发生，而本地登革热个案则于2013年7月至12月发生。登革热发病率在不同地理位置的年龄分布方面存在显著差异。然而，在广州、佛山和西双版纳发现了性别差异。DENV 1-3在疾病暴发的所有地点都被检测到。一些基因型在多个地点被检测到，并且在多个地点检测到多个基因型。传入暴发地区的登革热病毒主要来自东南亚。在广东省，登革1型病毒主要由广州市传播到邻近的佛山、中山等地，然后再传播到江门市。登革3型病毒由云南省西双版纳州传入广东省广州市。结论2013年中国登革热疫情可能是由东南亚登革热病毒的反复传入以及随后国内登革热在不同地区的传播引起的。
Background There was a dengue epidemic in several regions of China in 2013. No study has explored the dynamics of dengue transmission between different geographical locations with dengue outbreaks in China. The purpose of the study is to analyze the epidemiological characteristics and to explore the dynamic transmission of dengue in China, 2013. Methodology and Principal Findings Records of dengue cases of 2013 were obtained from the China Notifiable Disease Surveillance System. Full E-gene sequences of dengue virus detected from the outbreak regions of China were download from GenBank. Geographical Information System and heatmaps were used to describe the epidemiological characteristics. Maximum Likelihood phylogenetic and Bayesian phylogeographic analyses were conducted to explore the dengue dynamic transmission. Yunnan Province and Guangdong Province had the highest imported cases in the 2013 epidemic. In the locations with local dengue transmission, most of imported cases occurred from June to November 2013 while local dengue cases developed from July to December, 2013. There were significant variations for the incidences of dengue, in terms of age distributions, among different geographic locations. However, gender differences were identified in Guangzhou, Foshan and Xishuangbanna. DENV 1–3 were detected in all locations with the disease outbreaks. Some genotypes were detected in more than one locations and more than one genotypes have been detected in several locations. The dengue viruses introduced to outbreak areas were predominantly from Southeast Asia. In Guangdong Province, the phylogeographical results indicated that dengue viruses of DENV 1 were transmitted to neighboring cities Foshan and Zhongshan from Guangzhou city, and then transmitted to Jiangmen city. The virus in DENV 3 was introduced to Guangzhou city, Guangdong Province from Xishuangbanna prefecture, Yunnan Province. Conclusions Repeated dengue virus introductions from Southeast Asia and subsequent domestic dengue transmission within different regions may have contributed to the dengue epidemics in China, 2013.
登录
查看更多内容
影响因子：
1.9
作者：
Maciel-de-Freitas, R.;Souza-Santos, R.;Lourenco-de-Oliveira, R.
通讯作者：
Lourenco-de-Oliveira, R.
影响因子：
4.5
作者：
Peng HJ;Lai HB;Zhang QL;Xu BY;Zhang H;Liu WH;Zhao W;Zhou YP;Zhong XG;Jiang S;Duan JH;Yan GY;He JF;Chen XG
通讯作者：
Chen XG
1990 - 2014年中国登革热的流行病学变化：对全国25年的监视数据的描述性分析。
影响因子：
9.3
作者：
Lai S;Huang Z;Zhou H;Anders KL;Perkins TA;Yin W;Li Y;Mu D;Chen Q;Zhang Z;Qiu Y;Wang L;Zhang H;Zeng L;Ren X;Geng M;Li Z;Tatem AJ;Hay SI;Yu H
通讯作者：
Yu H
DOI：
10.4269/ajtmh.14-0588
发表时间：
2015-06
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Ng LC;Chem YK;Koo C;Mudin RNB;Amin FM;Lee KS;Kheong CC
通讯作者：
Kheong CC
影响因子：
3.7
作者：
Liu-Helmersson J;Stenlund H;Wilder-Smith A;Rocklöv J
通讯作者：
Rocklöv J