Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma.
Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma.
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DOI：
10.3390/jcm11061683
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发表时间：
2022-03-18
影响因子：
3.9
通讯作者：
Alou L
中科院分区：
文献类型：
--
作者：
Trevissón B;Becerro-de-Bengoa-Vallejo R;Sevillano D;González N;Losa-Iglesias ME;López-López D;Alou L
Few studies have checked the impact of the hormonal/immunological dimorphism of patients on the cellular composition of platelet-rich plasma products (PRP). Whole blood (WB) from 26 volunteers was concentrated using a device previously characterized. Platelet and white blood cell (WBC) counts in WB and PRP were compared between genders, and after the population was split into pre (≤50 years)- and post (>50 years)-menopausal ages. In WB, platelet–total WBC densities were comparable in men and women. The phagocytic cell composition differed (p ≤ 0.04). After dividing by ages, phagocytic cell discrepancies were linked to women > 50 years (p ≤ 0.05), and differences emerged in lymphocyte counts (lower in >50 years groups, within and between genders, p ≤ 0.05). In PRP, densities were significantly higher, but the PRP/WB ratios varied according to blood cell (lower for phagocytic cells) and between subjects (more favorable at a lower density of a particular blood cell in WB). This “system compensatory efficiency” reduced/reverted PRP differences in the leukocyte composition between genders/age–sex groups in WB. In PRP, neutrophils were higher in younger men than older women (p < 0.05). WB lymphocyte differences between age–sex groups persisted. Age is a more determining factor than sex in the preparation of PRP. Post-menopause, sexual dimorphism strongly influences the composition of leukocytes, also conditioned by the capture efficiency of the system.
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影响因子：
3.1
作者：
Han, Yanhong;Huang, Hetao;Liu, Jun
通讯作者：
Liu, Jun
影响因子：
4.8
作者：
Castillo, Tiffany N.;Pouliot, Michael A.;Dragoo, Jason L.
通讯作者：
Dragoo, Jason L.
影响因子：
1.2
作者：
Evanson, J. Richard;Guyton, M. Kelly;Bojescul, John A.
通讯作者：
Bojescul, John A.
影响因子：
3.4
作者：
Bain, BJ
通讯作者：
Bain, BJ
DOI：
10.1186/1742-4933-10-19
发表时间：
2013-05-15
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Hirokawa K;Utsuyama M;Hayashi Y;Kitagawa M;Makinodan T;Fulop T
通讯作者：
Fulop T