Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.
Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.
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DOI：
10.18632/aging.202305
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发表时间：
2020-12-19
期刊：
影响因子：
--
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Gao WQ;Hu XM;Zhang Q;Yang L;Lv XZ;Chen S;Wu P;Duan DW;Lang YH;Ning M;Lai KG;Zhang ZY;Liang B;Bao JY;Wu HD;Li T
环状RNA（Circular RNA，circRNA）是一类新型的内源性长链非编码RNA，由于其具有闭合连续环结构和潜在的临床应用价值而受到广泛关注。在这项研究中，我们研究了circFASTKD 1在血管内皮细胞中的功能。CircFASTKD 1直接与miR-106 a结合，并解除其对大肿瘤抑制激酶1和2的抑制，从而抑制Yes相关蛋白信号通路。在正常和缺氧条件下，circFASTKD 1的异位表达降低了血管内皮细胞的活力，迁移，流动性和管形成，而circFASTKD 1的下调通过促进这些过程诱导血管生成。此外，小鼠中circFASTKD 1的下调改善了心肌梗死后的心脏功能和修复。这些发现表明，circFASTKD 1是心肌梗死后血管生成的有效抑制剂，并且在缺氧期间沉默circFASTKD 1通过刺激体外和体内血管生成而发挥治疗作用。
Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a and relieved its inhibition of Large Tumor Suppressor Kinases 1 and 2, thereby suppressing the Yes-Associated Protein signaling pathway. Under both normal and hypoxic conditions, the ectopic expression of circFASTKD1 reduced the viability, migration, mobility and tube formation of vascular endothelial cells, whereas the downregulation of circFASTKD1 induced angiogenesis by promoting these processes. Moreover, downregulation of circFASTKD1 in mice improved cardiac function and repair after myocardial infarction. These findings indicate that circFASTKD1 is a potent inhibitor of angiogenesis after myocardial infarction and that silencing circFASTKD1 exerts therapeutic effects during hypoxia by stimulating angiogenesis in vitro and in vivo.
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影响因子：
8.8
作者：
Li J;Chen X;Ding X;Cheng Y;Zhao B;Lai ZC;Al Hezaimi K;Hakem R;Guan KL;Wang CY
通讯作者：
Wang CY
环状RNA YAP1通过调控miR-367-5p/p27 Kip1轴抑制胃癌细胞增殖和侵袭
影响因子：
37.3
作者：
Liu H;Liu Y;Bian Z;Zhang J;Zhang R;Chen X;Huang Y;Wang Y;Zhu J
通讯作者：
Zhu J
影响因子：
8.8
作者：
Cui, Yueli;Zheng, Yuxuan;Tang, Fuchou
通讯作者：
Tang, Fuchou
影响因子：
--
作者：
Park GS;Oh H;Kim M;Kim T;Johnson RL;Irvine KD;Lim DS
通讯作者：
Lim DS
DOI：
10.1002/advs.201800506
发表时间：
2018-09
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Landau S;Ben-Shaul S;Levenberg S
通讯作者：
Levenberg S