Cerebral blood flow changes in remitted early- and late-onset depression patients.
Cerebral blood flow changes in remitted early- and late-onset depression patients.
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早发型和晚发型抑郁症缓解患者的脑血流变化
DOI：
10.18632/oncotarget.19185
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发表时间：
2017-09-29
期刊：
影响因子：
--
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Liao W;Wang Z;Zhang X;Shu H;Wang Z;Liu D;Zhang Z
据报道，异常脑血流（CBF）与重度抑郁症（MDD）有关。我们研究了早发性抑郁症（EOD）和晚发性抑郁症（LOD）的脑血流变化及其对认知功能的影响。32例EOD缓解期患者、32例LOD缓解期患者和43例年龄匹配的健康对照者，在3.0T MRI下扫描脉冲动脉自旋标记数据，并通过逐体素统计分析进行处理。与健康对照组相比，LOD患者双侧楔前叶、楔叶、右侧额-扣带-纹状体区、右侧颞叶、枕叶和顶叶的标准化CBF降低，但左侧额、颞叶皮质和扣带回的标准化CBF增加。EOD患者左侧小脑和右侧距状回/舌回/梭状回的标准化CBF降低，右侧角回的标准化CBF升高。LOD患者的CBF表现为半球不对称性，且异常区域多于EOD患者。在LOD患者中检测到CBF异常与认知功能受损之间存在显著相关性，但在EOD患者中未检测到。这些结果表明LOD患者的CBF异常比EOD患者更大，并表明这些CBF变化可能与LOD患者的认知功能进行性退化有关。
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus. EOD patients had decreased normalized CBF in the left cerebellum and right calcarine/lingual/fusiform gyrus, and increased normalized CBF in right angular gyrus. LOD patients displayed hemispheric asymmetry in CBF, and had more regions with abnormal CBF than EOD patients. A significant correlation between abnormal CBF and impaired cognitive function was detected in LOD patients, but not EOD patients. These results demonstrate greater CBF abnormalities in LOD patients than EOD patients, and suggest these CBF changes may be associated with progressive degradation of cognitive function in LOD patients.
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影响因子：
3.7
作者：
Liang MJ;Zhou Q;Yang KR;Yang XL;Fang J;Chen WL;Huang Z
通讯作者：
Huang Z
DOI：
10.1016/j.jaac.2013.07.008
发表时间：
2013-10
影响因子：
13.3
作者：
Ho TC;Wu J;Shin DD;Liu TT;Tapert SF;Yang G;Connolly CG;Frank GK;Max JE;Wolkowitz O;Eisendrath S;Hoeft F;Banerjee D;Hood K;Hendren RL;Paulus MP;Simmons AN;Yang TT
通讯作者：
Yang TT
影响因子：
10.5
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
通讯作者：
O'Brien, John T.
影响因子：
2.3
作者：
Duhameau, Berengere;Ferre, Jean-Christophe;Drapier, Dominique
通讯作者：
Drapier, Dominique
影响因子：
6.7
作者：
Jarnum, Hanna;Eskildsen, Simon F.;Larsson, Elna-Marie
通讯作者：
Larsson, Elna-Marie