Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering.
Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering.
复制标题
作者：
本文综述了褐藻胶的研究进展和应用，海藻酸）和海藻酸盐杂化材料（AHM）。褐藻胶/褐藻胶是一种丰富的天然产物，具有化学惰性和生物相容性，并且具有上级凝胶特性、良好的机械强度和生物降解性。AHM已广泛应用于伤口敷料、细胞培养、组织工程和药物输送等领域。然而，不同领域的医疗应用对AHM的性能要求不同。药物递送应用要求AHM提供最佳药物装载、受控和靶向药物释放和/或视觉引导的药物递送。用于伤口敷料应用的AHM需要具有改善的机械性能、亲水性、细胞粘附性和抗菌性能。用于组织工程的AHM需要与靶器官匹配的改进的机械性能、上级细胞亲和力和细胞负载能力。总结了各种不同的方法来生产AHM，以满足不同的需求。形成具有改善的稳定性、药物/细胞负载能力、细胞粘附和机械性能的AHM的制剂是活跃的研究领域。这篇评论作为一个路线图，以提供深入了解的战略，以开发AHM在医疗应用。
In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications.
登录
查看更多内容
影响因子：
5.6
作者：
Araszkiewicz AM;Oliveira EP;Svendsen T;Drela K;Rogujski P;Malysz-Cymborska I;Fiedorowicz M;Reis RL;Oliveira JM;Walczak P;Janowski M;Lukomska B;Stanaszek L
通讯作者：
Stanaszek L
DOI：
10.1016/j.ijbiomac.2017.08.027
发表时间：
2018-01-01
影响因子：
8.2
作者：
Fernando, I. P. Shanura;Sanjeewa, K. K. Asanka;Jeon, You-Jin
通讯作者：
Jeon, You-Jin
负载阿霉素的聚（乳酸-乙醇酸）纳米颗粒通过逐层技术涂覆壳聚糖/海藻酸盐，用于抗肿瘤应用
影响因子：
8
作者：
Chai F;Sun L;He X;Li J;Liu Y;Xiong F;Ge L;Webster TJ;Zheng C
通讯作者：
Zheng C
影响因子：
4.6
作者：
Cai, Hong;Ni, Caihua;Zhang, Liping
通讯作者：
Zhang, Liping
DOI：
10.1016/j.jddst.2018.06.020
发表时间：
2018-10-01
影响因子：
5
作者：
Di Martino, Antonio;Trusova, Marina E.;Sedlarik, Vladimir
通讯作者：
Sedlarik, Vladimir