Interleukin-7 Plasma Levels in Human Differentiate Anorexia Nervosa, Constitutional Thinness and Healthy Obesity.
Interleukin-7 Plasma Levels in Human Differentiate Anorexia Nervosa, Constitutional Thinness and Healthy Obesity.
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DOI：
10.1371/journal.pone.0161890
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Galusca B
中科院分区：
文献类型：
--
作者：
Germain N;Viltart O;Loyens A;Bruchet C;Nadin K;Wolowczuk I;Estour B;Galusca B
白细胞介素-7（IL-7）是一种参与啮齿类动物能量稳态的细胞因子。神经性厌食症的特征是进食行为受限，尽管适应性食欲调节概况包括高ghrelin血浆水平。体质性消瘦是一种抵抗体重增加的生理状态，具有生理性增重特征，包括高肽YY血浆水平。健康肥胖可被认为是抵抗体重减轻的生理状态，具有与体质性瘦相反的食欲调节特征，包括低肽YY血浆水平。在这些人群中还没有IL-7的研究。因此，我们评估了神经性厌食症患者与体质性消瘦、健康肥胖和对照女性相比的IL-7昼夜血浆水平。10名限制型神经性厌食症女性、5名暴食/泻药型神经性厌食症女性、5名恢复的限制性神经性厌食症女性、4名贪食症女性、10名体质性消瘦女性、7名健康肥胖女性和10名正常体重女性对照被纳入这项横断面研究，在内分泌科和学术实验室进行。测量每个受试者血浆IL-7水平的昼夜节律曲线。24小时平均IL-7血浆水平（pg/ml，平均值±SEM）在限制型神经性厌食症中降低（123.4±14.4，p<0.0037），暴食/泻下型神经性厌食（24.2±5.6，p<0.001），限制性神经性厌食症恢复（64.2±16.1，p = 0.01）和健康肥胖患者（51±3.2，p<0.001）与对照组（187.7±28.6）相比。暴食症组（197.4±42.7）例，体质性消瘦组（264.3±35.8）例，与对照组相似。低IL-7是限制型神经性厌食症适应性特征的一部分，证实了其与体质性消瘦的差异。健康的肥胖，低IL-7，再次与正常高IL-7的体质性瘦成镜像。
Interleukin-7 (IL-7) is a cytokine involved in energy homeostasis as demonstrated in rodents. Anorexia nervosa is characterized by restrained eating behavior despite adaptive orexigenic regulation profile including high ghrelin plasma levels. Constitutional thinness is a physiological condition of resistance to weight gain with physiological anorexigenic profile including high Peptide YY plasma level. Healthy obesity can be considered as a physiological state of resistance to weight loss with opposite appetite regulating profile to constitutional thinness including low Peptide YY plasma level. No studies in IL-7 are yet available in those populations. Therefore we evaluated circadian plasma levels of IL-7 in anorexia nervosa compared to constitutional thinness, healthy obese and control females. 10 restrictive-type anorexia nervosa women, 5 bingeing/purging anorexia nervosa woman, 5 recovered restrictive anorexia nervosa women, 4 bulimic females, 10 constitutional thinness women, 7 healthy obese females, and 10 normal weight women controls were enrolled in this cross-sectional study, performed in endocrinology unit and academic laboratory. Twelve-point circadian profiles of plasma IL-7 levels were measured in each subject. 24h mean IL-7 plasma levels (pg/ml, mean±SEM) were decreased in restrictive-type anorexia nervosa (123.4±14.4, p<0.0037), bingeing/purging anorexia nervosa (24.2±5.6, p<0.001), recovered restrictive anorexia nervosa (64.2±16.1, p = 0.01) and healthy obese patients (51±3.2, p<0.001) compared to controls (187.7±28.6). Bulimic patients (197.4±42.7) and constitutional thinness patients (264.3±35.8) were similar to controls. Low IL-7 is part of the adaptive profile in restrictive-type anorexia nervosa, confirming its difference with constitutional thinness. Healthy obesity, with low IL-7, is once again in mirror image of constitutional thinness with normal high IL-7.
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影响因子：
15.1
作者：
Benedict, Christian;Dimitrov, Stoyan;Born, Jan
通讯作者：
Born, Jan
影响因子：
5.8
作者：
Balligand, JL;Brichard, SM;Lambert, M
通讯作者：
Lambert, M
影响因子：
7.1
作者：
MAZESS, RB;BARDEN, HS;HANSON, J
通讯作者：
HANSON, J
影响因子：
11.3
作者：
Brambilla, F;Monti, D;Franceschi, C
通讯作者：
Franceschi, C
影响因子：
3.7
作者：
Kahl, KG;Kruse, N;Schmidt, MH
通讯作者：
Schmidt, MH