Pterygium: an update on pathophysiology, clinical features, and management.
Pterygium: an update on pathophysiology, clinical features, and management.
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DOI：
10.1177/25158414211020152
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发表时间：
2021-01
影响因子：
2.5
通讯作者：
Feizi S
中科院分区：
文献类型：
--
作者：
Shahraki T;Arabi A;Feizi S
翼状胬肉是一种较为常见的眼表疾病。临床方面和治疗方案已经研究了多年，但仍然存在许多不确定性。核心病理途径和遗传在翼状胬肉发生中的作用仍然是研究人员感兴趣的领域。除了翼状胬肉切除术的屈光特性外，翼状胬肉在角膜不规则中的作用已通过大量研究得到越来越多的认识。翼状胬肉和眼表肿瘤之间的联系正在挑战关于该疾病安全性的传统观念。对综合性临床分类系统的需求促进了对翼状胬肉手术切除后复发率的试验和预测的同质化。随着手术方法的不断发展，出现了一些并发症，其诊断和处理对于眼科医生来说是必要的。根据综述，翼状胬肉进展的主要危险因素仍然是紫外线暴露。临床评估的主要部分应包括区分典型和非典型翼状胬肉，后者可能与眼表肿瘤的风险有关。翼状胬肉对散光和角膜像差的影响可能引起早期切除的需要，目的是减少继发性屈光不正。在手术方法中，结膜或结膜-角膜缘自体移植似乎是眼科医生的首选，因为据报道，与其他手术相比，该手术后的复发率较低。文献支持使用辅助治疗，术中和术后丝裂霉素C是辅助治疗的选择。抗血管内皮生长因子药物和环孢霉素的有效性和安全性已被假定;然而，它们在翼状胬肉治疗中的确切作用需要进一步研究。
Pterygium is a relatively common ocular surface disease. The clinical aspects and the treatment options have been studied since many years ago, but many uncertainties still exist. The core pathologic pathway and the role of heredity in the development of pterygium are still attractive fields for the researchers. The role of pterygium in corneal irregularities, in addition to the refractive properties of pterygium removal, has been increasingly recognized through numerous studies. The association between pterygium and ocular surface neoplasia is challenging the traditional beliefs regarding the safe profile of the disease. The need for a comprehensive clinical classification system has encouraged homogenization of trials and prediction of the recurrence rate of the pterygium following surgical removal. Evolving surgical methods have been associated with some complications, whose diagnosis and management are necessary for ophthalmic surgeons. According to the review, the main risk factor of pterygium progression remains to be the ultraviolet exposure. A major part of the clinical evaluation should consist of differentiating between typical and atypical pterygia, where the latter may be associated with the risk of ocular surface neoplasia. The effect of pterygium on astigmatism and the aberrations of the cornea may evoke the need for an early removal with a purpose of reducing secondary refractive error. Among the surgical methods, conjunctival or conjunctival-limbal autografting seems to be the first choice for ophthalmic surgeons because the recurrence rate following the procedure has been reported to be lower, compared with other procedures. The use of adjuvant options is supported in the literature, where intraoperative and postoperative mitomycin C has been the adjuvant treatment of choice. The efficacy and safety of anti–vascular endothelial growth factor agents and cyclosporine have been postulated; however, their exact role in the treatment of the pterygium requires further studies.
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影响因子：
2.4
作者：
Aidenloo, Naser Samadi;Motarjemizadeh, Qader;Heidarpanah, Maryam
通讯作者：
Heidarpanah, Maryam
影响因子：
4.1
作者：
CANOPARRA, J;DIAZLLOPIS, M;MENEZO, JL
通讯作者：
MENEZO, JL
影响因子：
2.8
作者：
Chen, Yeong-Fong;Hsiao, Ching-Hsi;Lin, Ken-Kuo
通讯作者：
Lin, Ken-Kuo
影响因子：
3.4
作者：
Chong, Pei Pei;Tung, Chee Hong;Yamamoto, Naoki
通讯作者：
Yamamoto, Naoki
DOI：
10.1016/j.sjopt.2017.11.002
发表时间：
2018-04
期刊：
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
影响因子：
--
作者：
Bilge AD
通讯作者：
Bilge AD