Differences in frontotemporal dysfunction during social and non-social cognition tasks between patients with autism spectrum disorder and schizophrenia.
Differences in frontotemporal dysfunction during social and non-social cognition tasks between patients with autism spectrum disorder and schizophrenia.
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DOI：
10.1038/s41598-018-21379-w
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发表时间：
2018-02-14
影响因子：
4.6
通讯作者：
Matsuo K
中科院分区：
文献类型：
--
作者：
Hirata K;Egashira K;Harada K;Nakashima M;Hirotsu M;Isomura S;Watanuki T;Matsubara T;Kaku Y;Kaneyuki H;Watanabe Y;Matsuo K
虽然文献证据表明自闭症谱系障碍（ASD）和精神分裂症（SCZ）患者的社会和非社会认知缺陷，但这两种疾病之间的神经相关性障碍的差异尚未阐明。我们使用功能性近红外光谱（fNIRS）在13例ASD患者、15例SCZ患者和18例健康受试者中检查了非社会认知和社会认知任务的脑功能。我们使用语言流畅性任务和情感面部识别任务评估了参与者的大脑功能。与健康受试者相比，ASD患者在两项任务中左额颞区的大脑激活显着减少。自闭症谱系商数中注意细节得分较高的ASD患者在两项任务中左额颞区的激活较低。与健康受试者相比，SCZ患者在语言流畅性任务期间在该区域的激活显着减少，而与ASD患者相比，激活更大。症状较重的SCZ患者在该区域的任务中大脑激活较低。我们的研究结果表明，两个不同的领域参与了独特的大脑病理生理学相关的认知处理与ASD和SCZ患者。
Although literature evidence suggests deficits in social and non-social cognition in patients with autistic spectrum disorder (ASD) and schizophrenia (SCZ), the difference in neural correlates of the impairments between the two disorders has not been elucidated. We examined brain function in response to a non-social cognition and a social cognition task using functional near-infrared spectroscopy (fNIRS) in 13 patients with ASD, 15 patients with SCZ, and 18 healthy subjects. We assessed the brain function of participants using a verbal fluency task and an emotional facial recognition task. The patients with ASD showed significantly reduced brain activation in the left frontotemporal area during both tasks compared to healthy subjects. The patients with ASD with larger score in ‘attention to detail’ in the autism spectrum quotient showed lower activation of the left frontotemporal area during the two tasks. The patients with SCZ showed significantly reduced activation, compared to healthy subjects, and greater activation, compared to patients with ASD, in the area during the verbal fluency task. The patients with SCZ with more severe symptoms had lower brain activation during the task in this area. Our results suggest that two distinct areas are involved in the distinctive brain pathophysiology relevant to cognitive processing in patients with ASD and SCZ.
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作者：
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影响因子：
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Järbrink, K;Knapp, M
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自闭症谱系障碍中杏仁核对情绪面孔的反应与社交焦虑之间的关联。
影响因子：
2.6
作者：
Kleinhans NM;Richards T;Weaver K;Johnson LC;Greenson J;Dawson G;Aylward E
通讯作者：
Aylward E