Translating advances from the basic biology of aging into clinical application.
Translating advances from the basic biology of aging into clinical application.
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DOI：
10.1016/j.exger.2012.11.014
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发表时间：
2013-01
影响因子：
3.9
通讯作者：
Kirkland, James L.
中科院分区：
文献类型：
--
作者：
Kirkland, James L.
最近，使用可能转化为人类的干预措施延长了实验动物的寿命和健康寿命。除了药物开发的常规步骤之外，还需要进行大量的思考和工作，以将这些发现推进临床应用。需要设计切合实际的临床前和临床试验范例。重点关注那些有年龄相关疾病或虚弱症状的受试者，或者那些即将出现这些问题的人，衡量对短期临床相关结果的影响，而不是对健康寿命或寿命等长期结果的影响，并开发监管机构可接受的生物标志物和结果测量方法，将是很重要的。研究经费是一个主要障碍，缺乏在衰老基础生物学、临床老年病学和开展研究性新药临床试验方面具有综合专业知识的研究人员也是一个主要障碍。选择审查，以发展从长凳到床边的干预措施，针对基本老化过程的路径。
Recently, lifespan and healthspan have been extended in experimental animals using interventions that are potentially translatable into humans. A great deal of thought and work are needed beyond the usual steps in drug development to advance these findings into clinical application. Realistic pre-clinical and clinical trials paradigms need to be devised. Focusing on subjects with symptoms of age-related diseases or frailty or who are at imminent risk of developing these problems, measuring effects on short-term, clinically relevant outcomes, as opposed to long-term outcomes such as healthspan or lifespan, and developing biomarkers and outcome measures acceptable to regulatory agencies will be important. Research funding is a major roadblock, as is lack of investigators with combined expertise in the basic biology of aging, clinical geriatrics, and conducting investigational new drug clinical trials. Options are reviewed for developing a path from the bench to the bedside for interventions that target fundamental aging processes.
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期刊：
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