Curcumin alleviates liver oxidative stress in type 1 diabetic rats.
Curcumin alleviates liver oxidative stress in type 1 diabetic rats.
复制标题
姜黄素减轻1型糖尿病大鼠中的肝氧化应激。
DOI：
10.3892/mmr.2017.7911
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发表时间：
2018-01
影响因子：
3.4
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Xie Z;Wu B;Shen G;Li X;Wu Q
本研究的目的是使用1型糖尿病大鼠模型确定姜黄素对抗氧化剂的影响。用链脲佐菌素（STZ）腹腔注射7周龄雄性Sprague-Dawley大鼠以诱导该模型，然后用1.0%姜黄素（重量比）混合在其饮食中治疗21天。本研究分为三组：对照组（NC）、糖尿病模型组（DC）和姜黄素治疗组（Diab-Cur）。结果表明，姜黄素能显著降低血糖水平、血浆丙二醛浓度、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）活性，提高超氧化物歧化酶（SOD）和胰岛素水平。姜黄素处理增加了CAT、GSH-Px、HO-1和NAD（P）H醌脱氢酶1的表达，降低了SOD 1的表达，从而降低了氧化应激状态。此外，姜黄素治疗显着增加了Diab-Cur组中Keap 1的蛋白表达，与DC组相比，降低了Nrf 2的胞浆浓度，同时增加了Nrf 2的核积累。结果提供了证据，表明姜黄素可以通过激活Keap 1-Nrf 2-ARE信号通路来减轻STZ诱导的糖尿病大鼠模型中的氧化应激，血糖浓度降低和几种抗氧化剂基因转录的增加就证明了这一点。
The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. Seven-week-old male Sprague-Dawley rats were injected with Streptozotocin (STZ) intraperitoneally to induce this model, and then treated with 1.0% curcumin (weight ratio) mixed in their diet for 21 days. The present study included three groups: Control group (NC), diabetic rat model group (DC) and a curcumin treated group (Diab-Cur). The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH-Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels. Curcumin treatment increased the expression of the CAT, GSH-Px, HO-1 and norvegicus NAD(P)H quinone dehydrogenase 1, and decreased the SOD1 expression, which, led to a diminished oxidative stress status. In addition, curcumin treatment significantly increased the protein expression of Keap1 in the Diab-Cur group when compared with the DC group, decreased cytosolic concentrations of Nrf2 while increasing nuclear accumulation of Nrf2. The results provide evidence that oxidative stress in the STZ-induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1-Nrf2-ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.
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DOI：
10.3390/molecules19068289
发表时间：
2014-06-18
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Jiménez-Flores LM;López-Briones S;Macías-Cervantes MH;Ramírez-Emiliano J;Pérez-Vázquez V
通讯作者：
Pérez-Vázquez V
影响因子：
7.4
作者：
Lenzen, S;Drinkgern, J;Tiedge, M
通讯作者：
Tiedge, M
影响因子：
5
作者：
Jin, Lei;Xue, Hong-Yu;Xu, Yong-Ping
通讯作者：
Xu, Yong-Ping
影响因子：
6.1
作者：
Gao, Qing;Shen, Wenwen;Liu, Zhihong
通讯作者：
Liu, Zhihong
影响因子：
4.3
作者：
Afanasiev, S. A.;Kondratieva, D. S.;Popov, S. V.
通讯作者：
Popov, S. V.