Error-related anterior cingulate cortex activity and the prediction of conscious error awareness.
Error-related anterior cingulate cortex activity and the prediction of conscious error awareness.
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DOI：
10.3389/fnhum.2012.00177
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发表时间：
2012
影响因子：
2.9
通讯作者：
Hester R
中科院分区：
文献类型：
--
作者：
Orr C;Hester R
研究与错误意识相关的神经机制的研究一直认为背侧前扣带回(ACC)的活动是必要的，但不能预测有意识的错误检测。最近的两项研究(Steinhauser和Yeung；Wessel等人)发现了在检测到的错误期间更大的背侧ACC(DACC)活动[以错误相关负性(ERN)的形式]的相反模式，但提出更大的活动可能相反地反映了任务影响(例如反应冲突、错误概率)和或个体变异性(例如统计能力)。我们重新分析了56名健康参与者的fMRI大胆数据，这些参与者之前曾接受过错误意识任务(EAT)，这是一种运动进行/不进行反应抑制任务，受试者犯下他们知道(知道错误)或不知道(不知道错误)的错误。与之前的数据一致，许多皮质区域的活动是错误意识的预测，包括双侧顶下皮质和岛叶皮质，然而，与之前的研究，包括我们自己使用相同任务的较小样本研究相比，与错误相关的dACC活动在有意识的错误期间显著高于不知道的错误。虽然知觉错误的反应时显著快于不知觉错误，与反应冲突增加ACC活性的假说一致，但我们没有发现错误反应时的差异与dACC活性之间的关系。数据表明，错误意识与与错误相关的dACC活动有关，但这一活动的作用可能与其他地区的活动相比更容易理解。DACC中的活动可能对有意识的错误检测很重要，但目前还不清楚什么任务和个人因素会影响错误意识。
Research examining the neural mechanisms associated with error awareness has consistently identified dorsal anterior cingulate cortex (ACC) activity as necessary but not predictive of conscious error detection. Two recent studies (Steinhauser and Yeung,; Wessel et al.,) have found a contrary pattern of greater dorsal ACC (dACC) activity [in the form of the error-related negativity (ERN)] during detected errors, but suggested that the greater activity may instead reflect task influences (e.g., response conflict, error probability) and or individual variability (e.g., statistical power). We re-analyzed fMRI BOLD data from 56 healthy participants who had previously been administered the Error Awareness Task (EAT), a motor Go/No-go response inhibition task in which subjects make errors of commission of which they are aware (Aware errors), or unaware (Unaware errors). Consistent with previous data, the activity in a number of cortical regions was predictive of error awareness, including bilateral inferior parietal and insula cortices, however, in contrast to previous studies, including our own smaller sample studies using the same task, error-related dACC activity was significantly greater during aware errors when compared to unaware errors. While the significantly faster RT for aware errors (compared to unaware) was consistent with the hypothesis of higher response conflict increasing ACC activity, we could find no relationship between dACC activity and the error RT difference. The data suggests that error awareness is associated with error-related dACC activity but that the role of this activity is probably best understood in relation to the activity in other regions. Activity in the dACC may be important to conscious error detection, but it remains unclear what task and individual factors influence error awareness.
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