Novel advances in strategies and applications of artificial articular cartilage.
Novel advances in strategies and applications of artificial articular cartilage.
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人工关节软骨的策略与应用新进展。
DOI：
10.3389/fbioe.2022.987999
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发表时间：
2022
影响因子：
5.7
通讯作者：
Fang, Jie
中科院分区：
文献类型：
--
作者：
Chen, Yifei;Zhang, Chenyue;Zhang, Shiyong;Qi, Hexu;Zhang, Donghui;Li, Yifei;Fang, Jie
人工关节软骨（AC）因其无血管、低细胞的特性而被广泛应用于缺乏自我再生能力的软骨的修复和再生。随着组织工程学的发展，人工AC的生物工程构建技术不断增加并逐渐成熟。本文综述了冷冻干燥、静电纺丝、3D生物打印、脱细胞等生物支架技术以及自组装、细胞片层等无支架技术在人工AC中的应用进展。本文介绍了几种利用支架和无支架技术构建的人工AC的成功应用，以证明人工AC的临床应用价值。
Artificial articular cartilage (AC) is extensively applied in the repair and regeneration of cartilage which lacks self-regeneration capacity because of its avascular and low-cellularity nature. With advances in tissue engineering, bioengineering techniques for artificial AC construction have been increasing and maturing gradually. In this review, we elaborated on the advances of biological scaffold technologies in artificial AC including freeze-drying, electrospinning, 3D bioprinting and decellularized, and scaffold-free methods such as self-assembly and cell sheet. In the following, several successful applications of artificial AC built by scaffold and scaffold-free techniques are introduced to demonstrate the clinical application value of artificial AC.
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影响因子：
5.6
作者：
Wasai S;Toyoda E;Takahashi T;Maehara M;Okada E;Uchiyama R;Akamatsu T;Watanabe M;Sato M
通讯作者：
Sato M
影响因子：
7.2
作者：
Kondo M;Kameishi S;Kim K;Metzler NF;Maak TG;Hutchinson DT;Wang AA;Maehara M;Sato M;Grainger DW;Okano T
通讯作者：
Okano T
影响因子：
4.6
作者：
Aisenbrey EA;Tomaschke A;Kleinjan E;Muralidharan A;Pascual-Garrido C;McLeod RR;Ferguson VL;Bryant SJ
通讯作者：
Bryant SJ
用于软骨组织工程的基于静电纺丝纳米纤维的超吸水性 3D 支架
影响因子：
9.5
作者：
Chen, Weiming;Chen, Shuai;Mo, Xiumei
通讯作者：
Mo, Xiumei
影响因子：
0.6
作者：
Bahrami, Naghmeh;Farzin, Ali;Ai, Jafar
通讯作者：
Ai, Jafar