Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.
Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.
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DOI：
10.1038/s41598-022-26871-y
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发表时间：
2023-01-20
影响因子：
4.6
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中科院分区：
文献类型：
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光学相干断层扫描血管造影 (OCTA) 是一种非侵入性高分辨率成像方式，在皮肤病学和微血管评估中的应用越来越广泛。皮肤中 OCTA 衍生的微血管参数的公认参考值尚不存在，但需要建立以推动 OCTA 进入临床。在这项试点研究中，我们评估了 52 名健康人和 11 名控制良好的 2 型糖尿病 (T2DM) 患者的手和脚在休息时和闭塞后反应性充血 (PORH) 后的一系列 OCTA 微血管指标。我们计算每个指标，测量测试重复性，并评估与人口统计风险因素的相关性。我们的研究提供了四肢特定的、与年龄相关的参考值以及九个微血管指标在基线和最大 PORH 时的重复性系数。手部与年龄相关的微血管指标没有观察到显着差异，但足部的几个指标却存在显着差异。对于大多数微血管指标，手部和足部的基线和最大 PORH 均存在显着差异，手部的值通常较高。尽管一系列个体之间存在很大差异，正如基于人口异质衰老表型所预期的那样，重测重复性为所有指标平均值的 3.5% 至 18%，这凸显了在更大队列中进行基于 OCTA 的研究、纵向监测和评估干预措施有效性的机会。此外，手足的分支点密度以及 PORH 引起的血管直径变化是健康组和 T2DM 组之间良好的区分因素，这表明它们作为生物标志物的潜在价值。这项研究以我们之前的工作为基础，代表着临床实践和研究中向标准化 OCTA 迈出了进一步的一步。
Optical coherence tomography angiography (OCTA) is a non-invasive, high-resolution imaging modality with growing application in dermatology and microvascular assessment. Accepted reference values for OCTA-derived microvascular parameters in skin do not yet exist but need to be established to drive OCTA into the clinic. In this pilot study, we assess a range of OCTA microvascular metrics at rest and after post-occlusive reactive hyperaemia (PORH) in the hands and feet of 52 healthy people and 11 people with well-controlled type 2 diabetes mellitus (T2DM). We calculate each metric, measure test–retest repeatability, and evaluate correlation with demographic risk factors. Our study delivers extremity-specific, age-dependent reference values and coefficients of repeatability of nine microvascular metrics at baseline and at the maximum of PORH. Significant differences are not seen for age-dependent microvascular metrics in hand, but they are present for several metrics in the foot. Significant differences are observed between hand and foot, both at baseline and maximum PORH, for most of the microvascular metrics with generally higher values in the hand. Despite a large variability over a range of individuals, as is expected based on heterogeneous ageing phenotypes of the population, the test–retest repeatability is 3.5% to 18% of the mean value for all metrics, which highlights the opportunities for OCTA-based studies in larger cohorts, for longitudinal monitoring, and for assessing the efficacy of interventions. Additionally, branchpoint density in the hand and foot and changes in vessel diameter in response to PORH stood out as good discriminators between healthy and T2DM groups, which indicates their potential value as biomarkers. This study, building on our previous work, represents a further step towards standardised OCTA in clinical practice and research.
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影响因子：
4.6
作者：
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