CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma.
CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma.
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DOI：
10.1186/s12885-018-4180-5
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发表时间：
2018-03-09
期刊：
影响因子：
3.8
通讯作者：
Brandau S
中科院分区：
文献类型：
--
作者：
Schlüter A;Weller P;Kanaan O;Nel I;Heusgen L;Höing B;Haßkamp P;Zander S;Mandapathil M;Dominas N;Arnolds J;Stuck BA;Lang S;Bankfalvi A;Brandau S
伴有淋巴转移的喉鳞状细胞癌（LSCC）患者预后相对较差，通常需要根治性治疗。驱动淋巴结转移的机制在很大程度上是未知的，但可能是由促血管生成的肿瘤微环境促进的。在本研究中，我们探讨了LSCC患者原发肿瘤中微血管的数量和血管内皮生长因子（VEGF）的表达水平是否与淋巴结转移程度（N期）、肿瘤分期（T）和生存时间相关。使用免疫组织化学分析了 97 名 LSCC 患者的组织微阵列。 VEGF 的表达按照染色强度（低与高）进行评分，并手动计数 CD31 阳性血管的数量（每个视野中位数 </≥7 条血管）。评分与 N 期、T 期和 5 年总生存率相关。血管生成生物标志物的高表达与整个患者队列中较差的总生存期无关。相反，高 CD31 计数与早期癌症相关 (p = 0.004)，而在该亚组中，高 VEGF 表达与较差的生存率相关 (p = 0.032)。此外，在早期癌症中，高血管计数与复发率增加相关（p = 0.004）。仅在早期亚组中，血管生成生物标志物的高表达与生存率降低和复发率增加相关。因此，血管生成的生物标志物可能有助于识别高危患者，特别是早期 LSCC。
Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenvironment. In this study, we examined whether the number of microvessels and the expression level of vascular endothelial growth factor (VEGF) in the primary tumor are correlated with the degree of lymph node metastasis (N-stage), tumor staging (T) and survival time in LSCC patients. Tissue-Microarrays of 97 LSCC patients were analyzed using immunohistochemistry. The expression of VEGF was scored as intensity of staining (low vs high) and the number of CD31-positive vessels (median </≥7 vessels per visual field) was counted manually. Scores were correlated with N-stage, T-stage and 5-year overall survival rate. A high expression of angiogenic biomarkers was not associated with poor overall survival in the overall cohort of patients. Instead high CD31 count was associated with early stage cancer (p = 0.004) and in this subgroup high VEGF expression correlated with poor survival (p = 0.032). Additionally, in early stage cancer a high vessel count was associated with an increased recurrence rate (p = 0.004). Only in the early stage subgroup a high expression of angiogenic biomarkers was associated with reduced survival and an increased rate of recurrence. Thus, biomarkers of angiogenesis may be useful to identify high risk patients specifically in early stage LSCC.
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影响因子：
2.6
作者：
Baek, Seung-Kuk;Jung, Kwang-Yoon;Chae, Yang-Seok
通讯作者：
Chae, Yang-Seok
影响因子：
9
作者：
FRANK, RE;SACLARIDES, TJ;RUBIN, DB
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RUBIN, DB
DOI：
10.1007/s00432-005-0003-6
发表时间：
2005-09-01
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3.6
作者：
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通讯作者：
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作者：
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9.7
作者：
CHAUDHURY, TK;LERNER, MP;NORDQUIST, RE
通讯作者：
NORDQUIST, RE