Age differences in the intrinsic functional connectivity of default network subsystems.
Age differences in the intrinsic functional connectivity of default network subsystems.
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DOI：
10.3389/fnagi.2013.00073
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发表时间：
2013
影响因子：
4.8
通讯作者：
Grady CL
中科院分区：
文献类型：
--
作者：
Campbell KL;Grigg O;Saverino C;Churchill N;Grady CL
最近的研究表明，默认模式网络（DMN）包括两个核心区域，腹内侧前额叶皮层和后扣带皮层（PCC），以及几个功能不同的独特子系统。这些包括内侧颞叶（MTL）子系统，在记忆和未来投射期间活跃，以及背内侧前额叶皮层（dmPFC）子系统，在自我参考期间活跃。PCC被进一步细分为腹侧（vPCC）和背侧（dPCC）区域，它们分别与DMN和认知控制网络连接更紧密。本研究的目的是检查这些子系统内静息状态功能连接的年龄差异。在应用严格的程序来减少头部运动的影响后，我们使用多变量技术来识别MTL与dmPFC以及vPCC与dPCC中常见和独特的功能连接模式。所有四个区域都与其他DMN区域具有强大的功能连接，并且每个区域在两个年龄组中也显示出不同的连接模式。年轻人和老年人在MTL子系统中具有相同的功能连接。老年人在vPCC和dmPFC子系统中表现出较弱的连接性，特别是与其他DMN区域的连接性，但在dPCC子系统中比年轻人的连接性更强，其中包括涉及认知控制的区域。我们的数据提供了证据，不同的子系统涉及DMN节点，这是保持与年龄。然而，有年龄差异的功能连接在这些子系统的强度，支持先前的证据表明，DMN连接是特别容易受到年龄的影响，而涉及认知控制区域的连接相对保持。这些结果表明，大脑网络之间的综合活动存在年龄差异，这可能对老年人的认知产生影响。
Recent work suggests that the default mode network (DMN) includes two core regions, the ventromedial prefrontal cortex and posterior cingulate cortex (PCC), and several unique subsystems that are functionally distinct. These include a medial temporal lobe (MTL) subsystem, active during remembering and future projection, and a dorsomedial prefrontal cortex (dmPFC) subsystem, active during self-reference. The PCC has been further subdivided into ventral (vPCC) and dorsal (dPCC) regions that are more strongly connected with the DMN and cognitive control networks, respectively. The goal of this study was to examine age differences in resting state functional connectivity within these subsystems. After applying a rigorous procedure to reduce the effects of head motion, we used a multivariate technique to identify both common and unique patterns of functional connectivity in the MTL vs. the dmPFC, and in vPCC vs. dPCC. All four areas had robust functional connectivity with other DMN regions, and each also showed distinct connectivity patterns in both age groups. Young and older adults had equivalent functional connectivity in the MTL subsystem. Older adults showed weaker connectivity in the vPCC and dmPFC subsystems, particularly with other DMN areas, but stronger connectivity than younger adults in the dPCC subsystem, which included areas involved in cognitive control. Our data provide evidence for distinct subsystems involving DMN nodes, which are maintained with age. Nevertheless, there are age differences in the strength of functional connectivity within these subsystems, supporting prior evidence that DMN connectivity is particularly vulnerable to age, whereas connectivity involving cognitive control regions is relatively maintained. These results suggest an age difference in the integrated activity among brain networks that can have implications for cognition in older adults.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
额顶认知控制网络的年龄差异：对注意力分散的影响。
影响因子：
2.6
作者：
Campbell KL;Grady CL;Ng C;Hasher L
通讯作者：
Hasher L
影响因子：
3.2
作者：
Grady, CL;Springer, MV;Winocur, G
通讯作者：
Winocur, G
影响因子：
5.7
作者：
Cole, Michael W.;Schneider, Walter
通讯作者：
Schneider, Walter