Fungi, fungicide discovery and global food security.
Fungi, fungicide discovery and global food security.
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DOI：
10.1016/j.fgb.2020.103476
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Gurr SJ
中科院分区：
文献类型：
--
作者：
Steinberg G;Gurr SJ
真菌对全球粮食安全构成最大的生物挑战。单一栽培是理想的真菌病原体饲养和繁殖场所。单一靶点杀菌剂是我们最好的“防御”，但抗药性已经出现。我们需要新的杀菌剂在“军备竞赛”中战胜病原体。学术和工业合作可以帮助杀菌剂的发现。为日益增长的世界人口确保足够的粮食对社会稳定和人类福祉至关重要。最近，很明显，真菌病原体对我们的卡路里作物构成了最大的生物挑战。此外，真菌病造成的商品作物损失破坏了发展中国家的经济稳定，从而增加了威胁的规模。我们控制这些病原体的最佳武器是杀真菌剂，但不断增加的耐药性使我们陷入了与它们的军备竞赛。需要发现新的抗真菌化合物，例如本文所述的单烷基亲脂性阳离子（MALC）。学术界和工业界之间的合作对于建立新的和有效的方法来开发这些新的杀真菌剂并将其推向市场至关重要。
Fungi pose the greatest biotic challenge to global food security. Monocultures are ideal fungal pathogen feeding and breeding grounds. Single target site fungicides are our best “defence”, but resistance has emerged. We need new fungicides to out-compete the pathogens in the “arms race”. Academic and industrial collaboration could help fungicide discovery. Securing sufficient food for a growing world population is of paramount importance for social stability and the well-being of mankind. Recently, it has become evident that fungal pathogens pose the greatest biotic challenge to our calorie crops. Moreover, the loss of commodity crops to fungal disease destabilises the economies of developing nations, thereby increasing the dimension of the threat. Our best weapon to control these pathogens is fungicides, but increasing resistance puts us in an arms race against them. New anti-fungal compounds need to be discovered, such as mono-alky lipophilic cations (MALCs) described herein. Collaborations between academia and industry are imperative to establish new and efficient ways to develop these new fungicides and to bring them to the market-place.
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